AGTRAP

AGTRAP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZV0, 4YAY
Identifiers
Aliases	AGTRAP, ATRAP, angiotensin II receptor associated protein
External IDs	OMIM: 608729; MGI: 1339977; HomoloGene: 7621; GeneCards: AGTRAP; OMA:AGTRAP - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	11,754,802 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	148,172,488 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; right uterine tube; ; pancreatic ductal cell; ; blood; ; gastric mucosa; ; spleen; ; right lung; ; upper lobe of left lung; ; bone marrow;
	Top expressed in
	blastocyst; ; right kidney; ; granulocyte; ; choroid plexus of fourth ventricle; ; proximal tubule; ; gastrula; ; Ileal epithelium; ; yolk sac; ; human kidney; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; angiotensin type II receptor activity;
Cellular component	integral component of membrane; Golgi membrane; plasma membrane; Golgi apparatus; cell cortex; endoplasmic reticulum membrane; cytoplasmic vesicle membrane; intracellular membrane-bounded organelle; endoplasmic reticulum; membrane; cytoplasmic vesicle; nucleoplasm; cytosol;
Biological process	regulation of blood pressure; angiotensin-activated signaling pathway; response to hypoxia;
	Sources:Amigo / QuickGO
Orthologs
	57085
	11610
	ENSG00000177674
	ENSMUSG00000029007
	Q6RW13
	Q9WVK0
	NM_001040194; NM_001040195; NM_001040196; NM_001040197; NM_020350
	NM_001301281; NM_009642
	NP_001035284; NP_001035285; NP_001035286; NP_001035287; NP_065083
	NP_001288210; NP_033772
	Wikidata
View/Edit Human	View/Edit Mouse

Type-1 angiotensin II receptor-associated protein is a protein that in humans is encoded by the AGTRAP gene.⁵⁶

This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.⁶

Interactions

AGTRAP has been shown to interact with GNB2L1.⁵

References

GRCh38: Ensembl release 89: ENSG00000177674 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029007 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wang W, Huang Y, Zhou Z, Tang R, Zhao W, Zeng L, Xu M, Cheng C, Gu S, Ying K, Xie Y, Mao Y (Dec 2001). "Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap)". Int J Biochem Cell Biol. 34 (1): 93–102. doi:10.1016/S1357-2725(01)00094-2. PMID 11733189.
"Entrez Gene: AGTRAP angiotensin II receptor-associated protein".

External links

Human AGTRAP genome location and AGTRAP gene details page in the UCSC Genome Browser.

Further reading

Daviet L, Lehtonen JY, Tamura K, et al. (1999). "Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor". J. Biol. Chem. 274 (24): 17058–62. doi:10.1074/jbc.274.24.17058. PMID 10358057.
Cui T, Nakagami H, Iwai M, et al. (2001). "ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth". Biochem. Biophys. Res. Commun. 279 (3): 938–41. doi:10.1006/bbrc.2000.4055. PMID 11162453.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. PMID 12107413.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lopez-Ilasaca M, Liu X, Tamura K, Dzau VJ (2004). "The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling". Mol. Biol. Cell. 14 (12): 5038–50. doi:10.1091/mbc.E03-06-0383. PMC 284805. PMID 12960423.
Guo DF, Chenier I, Tardif V, et al. (2003). "Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane". Biochem. Biophys. Res. Commun. 310 (4): 1254–65. doi:10.1016/j.bbrc.2003.09.154. PMID 14559250.
Guo DF, Tardif V, Ghelima K, et al. (2004). "A novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells". J. Biol. Chem. 279 (20): 21109–20. doi:10.1074/jbc.M401544200. PMID 14985364.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Guo S, Lopez-Ilasaca M, Dzau VJ (2005). "Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation". J. Biol. Chem. 280 (13): 12536–41. doi:10.1074/jbc.M500296200. PMID 15668245.
Tanaka Y, Tamura K, Koide Y, et al. (2005). "The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy". FEBS Lett. 579 (7): 1579–86. doi:10.1016/j.febslet.2005.01.068. PMID 15757644. S2CID 36456303.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177674 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029007 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11733189-5] Wang W, Huang Y, Zhou Z, Tang R, Zhao W, Zeng L, Xu M, Cheng C, Gu S, Ying K, Xie Y, Mao Y (Dec 2001). "Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap)". Int J Biochem Cell Biol. 34 (1): 93–102. doi:10.1016/S1357-2725(01)00094-2. PMID 11733189.

[entrez-6] "Entrez Gene: AGTRAP angiotensin II receptor-associated protein".

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