Article · Wikipedia archive · Last revised Jun 18, 2026

ADAMTS14

ADAMTS14 encodes a member of the ADAMTS protein family. Family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The proteolytic process of the encoded preproprotein generates a mature enzyme. The enzyme cleaves the amino-propeptides of fibrillar collagens, enabling collagen fibril formation before the assembly of collagen, a major extracellular matrix (ECM) protein.

Last revised
Jun 18, 2026
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ADAMTS14 encodes a member of the ADAMTS protein family. Family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The proteolytic process of the encoded preproprotein generates a mature enzyme. The enzyme cleaves the amino-propeptides of fibrillar collagens, enabling collagen fibril formation before the assembly of collagen, a major extracellular matrix (ECM) protein.12

References

References

  1. "ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif 14 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-05-19. This article incorporates text from this source, which is in the public domain.
  2. "ADAMTS14 Gene - GeneCards | ATS14 Protein | ATS14 Antibody". www.genecards.org. Retrieved 2022-05-19.