ACTL6B

ACTL6B
Identifiers
Aliases	ACTL6B, ACTL6, BAF53B, arpNalpha, actin like 6B, EIEE76, IDDSSAD, DEE76, SMARCN2
External IDs	OMIM: 612458; MGI: 1933548; HomoloGene: 81844; GeneCards: ACTL6B; OMA:ACTL6B - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	100,656,448 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	137,569,582 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; ganglionic eminence; ; Brodmann area 9; ; prefrontal cortex; ; nucleus accumbens; ; cingulate gyrus; ; anterior cingulate cortex; ; putamen; ; caudate nucleus;
	Top expressed in
	superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; perirhinal cortex; ; subiculum; ; entorhinal cortex; ; cerebellar cortex; ; olfactory tubercle; ; dorsomedial hypothalamic nucleus; ; CA3 field;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	structural constituent of cytoskeleton; transcription coactivator activity; chromatin binding;
Cellular component	nucleus; nucleolus; nBAF complex; SWI/SNF complex; NuA4 histone acetyltransferase complex;
Biological process	nervous system development; regulation of transcription, DNA-templated; spinal cord development; regulation of transcription by RNA polymerase II; transcription, DNA-templated; chromatin remodeling; cytoskeleton organization; chromatin organization; positive regulation of nucleic acid-templated transcription; histone H4 acetylation;
	Sources:Amigo / QuickGO
Orthologs
	51412
	83766
	ENSG00000077080
	ENSMUSG00000029712
	O94805
	Q99MR0
	NM_016188
	NM_031404
	NP_057272
	NP_113581
	Wikidata
View/Edit Human	View/Edit Mouse

Actin-like protein 6B is a protein that in humans is encoded by the ACTL6B gene.⁵⁶

Function

The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.⁶

Interactions

ACTL6B has been shown to interact with CTBP1.⁷

References

GRCh38: Ensembl release 89: ENSG00000077080 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029712 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (December 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Res. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.
"Entrez Gene: ACTL6B actin-like 6B".
Oma Y, Nishimori K, Harata M (February 2003). "The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP". Biochem. Biophys. Res. Commun. 301 (2): 521–528. doi:10.1016/S0006-291X(02)03073-5. PMID 12565893.

External links

Human ACTL6B genome location and ACTL6B gene details page in the UCSC Genome Browser.

Further reading

Schafer DA, Schroer TA (2000). "Actin-related proteins". Annu. Rev. Cell Dev. Biol. 15: 341–363. doi:10.1146/annurev.cellbio.15.1.341. PMID 10611965.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Harata M, Mochizuki R, Mizuno S (1999). "Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues". Biosci. Biotechnol. Biochem. 63 (5): 917–923. doi:10.1271/bbb.63.917. PMID 10380635.
Olave I, Wang W, Xue Y, Kuo A, Crabtree GR (2002). "Identification of a polymorphic, neuron-specific chromatin remodeling complex". Genes Dev. 16 (19): 2509–2517. doi:10.1101/gad.992102. PMC 187451. PMID 12368262.
Kuroda Y, Oma Y, Nishimori K, Ohta T, Harata M (2003). "Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex". Biochem. Biophys. Res. Commun. 299 (2): 328–334. doi:10.1016/S0006-291X(02)02637-2. PMID 12437990.
Oma Y, Nishimori K, Harata M (2003). "The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP". Biochem. Biophys. Res. Commun. 301 (2): 521–528. doi:10.1016/S0006-291X(02)03073-5. PMID 12565893.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000077080 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029712 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9799793-5] Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (December 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Res. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.

[entrez-6] "Entrez Gene: ACTL6B actin-like 6B".

[pmid12565893-7] Oma Y, Nishimori K, Harata M (February 2003). "The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP". Biochem. Biophys. Res. Commun. 301 (2): 521–528. doi:10.1016/S0006-291X(02)03073-5. PMID 12565893.

1

2

3

4

5

6

7