Article · Wikipedia archive · Last revised Jun 30, 2026

AC927

AC927 or 1-(2-phenylethyl)piperidine is a selective sigma receptor antagonist, with reported binding affinity of Ki = 30 ± 2 nM for the sigma-1 receptor and Ki = 138 ± 18 nM for the sigma-2 receptor, and negligible binding affinity for other major central nervous system receptors, transporters, and ion channels.

Last revised
Jun 30, 2026
Read time
≈ 1 min
Length
127 w
Citations
2
Source
Wikipedia ↗
AC927
Clinical data
Other names1-Phenethylpiperidine; pip-PEA; Phenylethylpiperidine
Identifiers
  • 1-(2-phenylethyl)piperidine or N-phenethyl-piperidine
CAS Number
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.005.785
Chemical and physical data
FormulaC13H19N
Molar mass189.302 g·mol−1

AC927 or 1-(2-phenylethyl)piperidine is a selective sigma receptor antagonist, with reported binding affinity of Ki = 30 ± 2 nM for the sigma-1 receptor and Ki = 138 ± 18 nM for the sigma-2 receptor, and negligible binding affinity for other major central nervous system receptors, transporters, and ion channels.1

AC927 is reported to attenuate the locomotor stimulation induced by methamphetamine in mice.1

References

References