ABCA9

ABCA9
Identifiers
Aliases	ABCA9, EST640918, ATP binding cassette subfamily A member 9
External IDs	OMIM: 612507; MGI: 2386796; HomoloGene: 33332; GeneCards: ABCA9; OMA:ABCA9 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	69,060,949 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	110,059,022 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; tibial nerve; ; sural nerve; ; left ovary; ; myocardium of left ventricle; ; subcutaneous adipose tissue; ; right ovary; ; cardiac muscle tissue of right atrium; ; pericardium; ; apex of heart;
	Top expressed in
	sciatic nerve; ; ciliary body; ; vestibular sensory epithelium; ; stroma of bone marrow; ; otolith organ; ; iris; ; utricle; ; dermis; ; umbilical cord; ; conjunctival fornix;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; ATPase activity; ATP binding; ATPase-coupled transmembrane transporter activity; lipid transporter activity;
Cellular component	integral component of membrane; membrane; intracellular membrane-bounded organelle;
Biological process	lipid transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	10350
	217262
	ENSG00000154258
	ENSMUSG00000041797
	Q8IUA7
	Q8K449
	NM_080283; NM_172386
	NM_147220
	NP_525022
	NP_671753
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-binding cassette sub-family A member 9 is a protein that in humans is encoded by the ABCA9 gene.⁵

Function

This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two transmembrane domains and two nucleotide binding folds. ABC proteins transport various molecules across extra- and intracellular membranes. This gene is a member of the ABCA subfamily and is clustered with four other ABCA subfamily members on chromosome 17q24. Transcriptional expression of this gene is induced during monocyte differentiation into macrophages and is suppressed by cholesterol import.⁵

References