Article · Wikipedia archive · Last revised Jun 26, 2026

2-MAPB

2-MAPB is a recreational designer drug with empathogenic effects. As with other related substituted benzofuran derivatives such as 6-APB and 5-MAPB, 2-MAPB is a monoamine releaser with some selectivity for serotonin release, generally similar in pharmacological profile to MDMA but with greater activity as a directly acting agonist of 5-HT2 receptor subtypes and somewhat greater toxicity. 2-MAPB has been isolated from post-mortem toxicology screens in several drug-related fatal adverse reactions but generally only as a component of combinations of drugs, making it difficult to determine how much it contributed to the deaths. It is illegal in Japan.

Last revised
Jun 26, 2026
Read time
≈ 1 min
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Citations
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2-MAPB
Identifiers
  • 1-(1-benzofuran-2-yl)-N-methylpropan-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC12H15NO
Molar mass189.258 g·mol−1
3D model (JSmol)
  • CC(CC1=CC2=CC=CC=C2O1)NC
  • InChI=1S/C12H15NO/c1-9(13-2)7-11-8-10-5-3-4-6-12(10)14-11/h3-6,8-9,13H,7H2,1-2H3
  • Key:ANJIDHKQUCZNQY-UHFFFAOYSA-N

2-MAPB is a recreational designer drug with empathogenic effects. As with other related substituted benzofuran derivatives such as 6-APB and 5-MAPB, 2-MAPB is a monoamine releaser with some selectivity for serotonin release, generally similar in pharmacological profile to MDMA but with greater activity as a directly acting agonist of 5-HT2 receptor subtypes and somewhat greater toxicity.1 2-MAPB has been isolated from post-mortem toxicology screens in several drug-related fatal adverse reactions but generally only as a component of combinations of drugs, making it difficult to determine how much it contributed to the deaths.23 It is illegal in Japan.4

See also

See also

References

References

  1. Fuwa T, Suzuki J, Tanaka T, Inomata A, Honda Y, Kodama T (2016). "Novel psychoactive benzofurans strongly increase extracellular serotonin level in mouse corpus striatum". The Journal of Toxicological Sciences. 41 (3): 329–337. doi:10.2131/jts.41.329. PMID 27193726.
  2. Staeheli SN, Boxler MI, Oestreich A, Marti M, Gascho D, Bolliger SA, et al. (October 2017). "Postmortem distribution and redistribution of MDAI and 2-MAPB in blood and alternative matrices" (PDF). Forensic Science International. 279: 83–87. doi:10.1016/j.forsciint.2017.08.007. PMID 28850871. S2CID 31183795.
  3. Theofel N, Budach D, Vejmelka E, Scholtis S, Tsokos M (June 2021). "Toxicological investigations in a death involving 2-MAPB". Forensic Science, Medicine, and Pathology. 17 (2): 317–321. doi:10.1007/s12024-021-00366-0. ISSN 1547-769X. PMID 33877515. S2CID 233309570.
  4. "指定薬物名称・構造式一覧（平成27年9月16日現在）" (PDF) (in Japanese). 厚生労働省. 16 September 2015. Retrieved 23 August 2016.