ZRANB2

ZRANB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1N0Z, 2K1P, 3G9Y
Identifiers
Aliases	ZRANB2, ZIS, ZIS1, ZIS2, ZNF265, zinc finger RANBP2-type containing 2
External IDs	OMIM: 604347; MGI: 1858211; HomoloGene: 135921; GeneCards: ZRANB2; OMA:ZRANB2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	71,081,289 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	157,254,047 bp
RNA expression pattern
	Top expressed in
	pancreatic epithelial cell; ; mucosa of ileum; ; Achilles tendon; ; cardiac muscle tissue of right atrium; ; corpus epididymis; ; caput epididymis; ; tibialis anterior muscle; ; anterior pituitary; ; tibia; ; myocardium of left ventricle;
	Top expressed in
	genital tubercle; ; tail of embryo; ; medullary collecting duct; ; neural layer of retina; ; renal corpuscle; ; cerebellar cortex; ; atrioventricular valve; ; olfactory bulb; ; vestibular membrane of cochlear duct; ; primitive streak;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; protein binding; metal ion binding; RNA binding; lipopolysaccharide binding;
Cellular component	nucleus; nucleoplasm;
Biological process	mRNA processing; RNA splicing; regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	9406
	53861
	ENSG00000132485
	ENSMUSG00000028180
	O95218
	Q9R020
	NM_005455; NM_203350
	NM_017381; NM_001355381; NM_001355386
	NP_005446; NP_976225
	NP_059077; NP_001342310; NP_001342315
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger Ran-binding domain-containing protein 2 is a protein that in humans is encoded by the ZRANB2 gene.⁵⁶

Interactions

ZRANB2 has been shown to interact with U2 small nuclear RNA auxiliary factor 1⁷ and SNRP70.⁷

References

GRCh38: Ensembl release 89: ENSG00000132485 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028180 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nakano M, Yoshiura K, Oikawa M, Miyoshi O, Yamada K, Kondo S, Miwa N, Soeda E, Jinno Y, Fujii T, Niikawa N (February 1999). "Identification, characterization and mapping of the human ZIS (zinc-finger, splicing) gene". Gene. 225 (1–2): 59–65. doi:10.1016/S0378-1119(98)00536-8. PMID 9931435.
"Entrez Gene: ZRANB2 zinc finger, RAN-binding domain containing 2".
Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE (July 2001). "ZNF265--a novel spliceosomal protein able to induce alternative splicing". J. Cell Biol. 154 (1): 25–32. doi:10.1083/jcb.200010059. PMC 2196870. PMID 11448987.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Adams DJ, van der Weyden L, Kovacic A, Lovicu FJ, Copeland NG, Gilbert DJ, Jenkins NA, Ioannou PA, Morris BJ (2000). "Chromosome localization and characterization of the mouse and human zinc finger protein 265 gene". Cytogenet. Cell Genet. 88 (1–2): 68–73. doi:10.1159/000015487. PMID 10773668. S2CID 43262249.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE (2001). "ZNF265--a novel spliceosomal protein able to induce alternative splicing". J. Cell Biol. 154 (1): 25–32. doi:10.1083/jcb.200010059. PMC 2196870. PMID 11448987.
Plambeck CA, Kwan AH, Adams DJ, Westman BJ, van der Weyden L, Medcalf RL, Morris BJ, Mackay JP (2003). "The structure of the zinc finger domain from human splicing factor ZNF265 fold". J. Biol. Chem. 278 (25): 22805–22811. doi:10.1074/jbc.M301896200. PMID 12657633.
Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–7447. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Mangs AH, Speirs HJ, Goy C, Adams DJ, Markus MA, Morris BJ (2006). "XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265". Nucleic Acids Res. 34 (17): 4976–4986. doi:10.1093/nar/gkl660. PMC 1635291. PMID 16982639.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

ZRANB2 human gene location in the UCSC Genome Browser.
ZRANB2 human gene details in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132485 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028180 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9931435-5] Nakano M, Yoshiura K, Oikawa M, Miyoshi O, Yamada K, Kondo S, Miwa N, Soeda E, Jinno Y, Fujii T, Niikawa N (February 1999). "Identification, characterization and mapping of the human ZIS (zinc-finger, splicing) gene". Gene. 225 (1–2): 59–65. doi:10.1016/S0378-1119(98)00536-8. PMID 9931435.

[entrez-6] "Entrez Gene: ZRANB2 zinc finger, RAN-binding domain containing 2".

[pmid11448987-7] Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE (July 2001). "ZNF265--a novel spliceosomal protein able to induce alternative splicing". J. Cell Biol. 154 (1): 25–32. doi:10.1083/jcb.200010059. PMC 2196870. PMID 11448987.

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