ZFP91

ZFP91
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M9A
Identifiers
Aliases	ZFP91, DMS-8, DSM-8, PZF, ZFP-91, ZNF757, FKSG11, ZFP91 zinc finger protein, ZFP91 zinc finger protein, atypical E3 ubiquitin ligase, DSM8
External IDs	MGI: 104854; HomoloGene: 43144; GeneCards: ZFP91; OMA:ZFP91 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	58,621,550 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	12,773,490 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; mucosa of ileum; ; myocardium of left ventricle; ; deltoid muscle; ; cardiac muscle tissue of right atrium; ; cerebellar vermis; ; skin of arm; ; sperm; ; quadriceps femoris muscle; ; cartilage tissue;
	Top expressed in
	ascending aorta; ; aortic valve; ; Rostral migratory stream; ; soleus muscle; ; gastrocnemius muscle; ; tibialis anterior muscle; ; plantaris muscle; ; extensor digitorum longus muscle; ; ankle; ; quadriceps femoris muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; nucleic acid binding; ubiquitin-protein transferase activity; transferase activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleolus;
Biological process	protein K63-linked ubiquitination; activation of NF-kappaB-inducing kinase activity; protein ubiquitination; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	80829
	109910
	ENSG00000186660
	ENSMUSG00000024695
	Q96JP5
	Q62511
	NM_053023; NM_001197051
	NM_053009
	NP_001183980; NP_444251
	NP_443735
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein 91 homolog is a protein that in humans is encoded by the ZFP91 gene.⁵⁶

The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2 type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. In addition to the monocistronic transcript originating from this locus, a co-transcribed variant composed of ZFP91 and CNTF sequence has been identified. The monocistronic and co-transcribed variants encode distinct isoforms. The co-transcription of ZFP91 and CNTF has also been observed in mouse.⁶

References

GRCh38: Ensembl release 89: ENSG00000186660 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024695 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Unoki M, Okutsu J, Nakamura Y (May 2003). "Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia". Int J Oncol. 22 (6): 1217–23. doi:10.3892/ijo.22.6.1217. PMID 12738986.
"Entrez Gene: ZFP91 zinc finger protein 91 homolog (mouse)".

Further reading

Iuchi S (2001). "Three classes of C2H2 zinc finger proteins". Cell. Mol. Life Sci. 58 (4): 625–35. doi:10.1007/PL00000885. PMC 11146492. PMID 11361095. S2CID 6522993.
Grottke C, Mantwill K, Dietel M, et al. (2000). "Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs". Int. J. Cancer. 88 (4): 535–46. doi:10.1002/1097-0215(20001115)88:4<535::AID-IJC4>3.0.CO;2-V. PMID 11058868. S2CID 24030621.
Yu Y, Zhang C, Zhou G, et al. (2001). "Gene Expression Profiling in Human Fetal Liver and Identification of Tissue- and Developmental-Stage-Specific Genes through Compiled Expression Profiles and Efficient Cloning of Full-Length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Tompkins V, Hagen J, Zediak VP, Quelle DE (2006). "Identification of novel ARF binding proteins by two-hybrid screening". Cell Cycle. 5 (6): 641–6. doi:10.4161/cc.5.6.2560. PMID 16582619.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186660 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024695 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12738986-5] Unoki M, Okutsu J, Nakamura Y (May 2003). "Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia". Int J Oncol. 22 (6): 1217–23. doi:10.3892/ijo.22.6.1217. PMID 12738986.

[entrez-6] "Entrez Gene: ZFP91 zinc finger protein 91 homolog (mouse)".

1

2

3

4

5

6