XCL2

XCL2
Identifiers
Aliases	XCL2, SCM-1b, SCM1B, SCYC2, chemokine (C motif) ligand 2, X-C motif chemokine ligand 2
External IDs	OMIM: 604828; MGI: 104593; HomoloGene: 130513; GeneCards: XCL2; OMA:XCL2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	168,543,997 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	164,763,096 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; spleen; ; blood; ; lymph node; ; bone marrow; ; duodenum; ; appendix; ; epithelium of colon; ; placenta; ; right lobe of liver;
	Top expressed in
	thymus; ; granulocyte; ; mesenteric lymph nodes; ; spleen; ; blood; ; choroid plexus of fourth ventricle; ; right kidney; ; secondary oocyte; ; jejunum; ; uterus;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; protein binding; CCR chemokine receptor binding; chemokine activity;
Cellular component	extracellular region; extracellular space;
Biological process	monocyte chemotaxis; chemokine-mediated signaling pathway; cellular response to tumor necrosis factor; blood circulation; neutrophil chemotaxis; chemotaxis; positive regulation of GTPase activity; cellular response to interleukin-1; immune response; positive regulation of ERK1 and ERK2 cascade; cellular response to interferon-gamma; lymphocyte chemotaxis; inflammatory response; signal transduction; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; positive regulation of T cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	6846
	16963
	ENSG00000143185
	ENSMUSG00000026573
	Q9UBD3
	P47993
	NM_003175
	NM_008510
	NP_003166
	NP_032536
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine (C motif) ligand 2 (XCL2) is a small cytokine belonging to the XC chemokine family that is highly related to another chemokine called XCL1.⁵ It is predominantly expressed in activated T cells, but can also be found at low levels in unstimulated cells. XCL2 induces chemotaxis of cells expressing the chemokine receptor XCR1.⁶ Its gene is located on chromosome 1 in humans.⁷

References

GRCh38: Ensembl release 89: ENSG00000143185 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026573 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kennedy J, Kelner G, Kleyensteuber S, Schall T, Weiss M, Yssel H, Schneider P, Cocks B, Bacon K, Zlotnik A (1995). "Molecular cloning and functional characterization of human lymphotactin". J Immunol. 155 (1): 203–9. doi:10.4049/jimmunol.155.1.203. PMID 7602097.
Yoshida T, Imai T, Kakizaki M, Nishimura M, Takagi S, Yoshie O (1998). "Identification of single C motif-1/lymphotactin receptor XCR1". J Biol Chem. 273 (26): 16551–4. doi:10.1074/jbc.273.26.16551. PMID 9632725.
Yoshida T, Imai T, Takagi S, Nishimura M, Ishikawa I, Yaoi T, Yoshie O (1996). "Structure and expression of two highly related genes encoding SCM-1/human lymphotactin". FEBS Lett. 395 (1): 82–8. Bibcode:1996FEBSL.395...82Y. doi:10.1016/0014-5793(96)01004-6. PMID 8849694.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143185 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026573 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Kennedy J, Kelner G, Kleyensteuber S, Schall T, Weiss M, Yssel H, Schneider P, Cocks B, Bacon K, Zlotnik A (1995). "Molecular cloning and functional characterization of human lymphotactin". J Immunol. 155 (1): 203–9. doi:10.4049/jimmunol.155.1.203. PMID 7602097.

[6] Yoshida T, Imai T, Kakizaki M, Nishimura M, Takagi S, Yoshie O (1998). "Identification of single C motif-1/lymphotactin receptor XCR1". J Biol Chem. 273 (26): 16551–4. doi:10.1074/jbc.273.26.16551. PMID 9632725.

[7] Yoshida T, Imai T, Takagi S, Nishimura M, Ishikawa I, Yaoi T, Yoshie O (1996). "Structure and expression of two highly related genes encoding SCM-1/human lymphotactin". FEBS Lett. 395 (1): 82–8. Bibcode:1996FEBSL.395...82Y. doi:10.1016/0014-5793(96)01004-6. PMID 8849694.

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