WNT8B

WNT8B
Identifiers
Aliases	WNT8B, Wnt family member 8B
External IDs	OMIM: 601396; MGI: 109485; HomoloGene: 2550; GeneCards: WNT8B; OMA:WNT8B - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	100,483,744 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	44,502,712 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; renal cortex; ; human kidney; ; right testis; ; left testis; ; olfactory zone of nasal mucosa; ; granulocyte; ; liver; ; urinary bladder; ; prostate;
	Top expressed in
	corneal epithelium; ; lumbar subsegment of spinal cord; ; set of lens fibers; ; vein; ; ascending aorta; ; embryo; ; corneal endothelium; ; aortic valve; ; corneal stroma; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; frizzled binding; receptor ligand activity;
Cellular component	extracellular region; extracellular space;
Biological process	multicellular organism development; cellular response to retinoic acid; cell fate commitment; determination of dorsal identity; response to estradiol; gastrulation; response to retinoic acid; neuron differentiation; signal transduction; nervous system development; beta-catenin destruction complex disassembly; Wnt signaling pathway; regulation of signaling receptor activity; canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7479
	22423
	ENSG00000075290
	ENSMUSG00000036961
	Q93098
	Q9WUD6
	NM_003393
	NM_011720
	NP_003384
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Wnt-8b is a protein that in humans is encoded by the WNT8B gene.⁵⁶

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis.

This gene is a member of the WNT gene family. It encodes a protein showing 95%, 86%, and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy.⁶

References

GRCh38: Ensembl release 89: ENSG00000075290 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000036961 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lako M, Strachan T, Curtis AR, Lindsay S (Sep 1996). "Isolation and characterization of WNT8B, a novel human Wnt gene that maps to 10q24". Genomics. 35 (2): 386–8. doi:10.1006/geno.1996.0374. PMID 8661156.
"Entrez Gene: WNT8B wingless-type MMTV integration site family, member 8B".

Further reading

Katoh M, Katoh M (2007). "Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs". Int. J. Oncol. 30 (5): 1273–7. doi:10.3892/ijo.30.5.1273. PMID 17390031.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Saitoh T, Mine T, Katoh M (2002). "Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: up-regulation of WNT8B mRNA by beta-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells". Int. J. Oncol. 20 (5): 999–1003. doi:10.3892/ijo.20.5.999. PMID 11956596.
Saitoh T, Mine T, Katoh M (2002). "Up-regulation of WNT8B mRNA in human gastric cancer". Int. J. Oncol. 20 (2): 343–8. doi:10.3892/ijo.20.2.343. PMID 11788899.
Lako M, Lindsay S, Bullen P, et al. (1998). "A novel mammalian wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain". Hum. Mol. Genet. 7 (5): 813–22. doi:10.1093/hmg/7.5.813. PMID 9536085.
Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC 275763. PMID 8167409.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000075290 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036961 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8661156-5] Lako M, Strachan T, Curtis AR, Lindsay S (Sep 1996). "Isolation and characterization of WNT8B, a novel human Wnt gene that maps to 10q24". Genomics. 35 (2): 386–8. doi:10.1006/geno.1996.0374. PMID 8661156.

[entrez-6] "Entrez Gene: WNT8B wingless-type MMTV integration site family, member 8B".

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