WNT11

WNT11
Identifiers
Aliases	WNT11, HWnt family member 11
External IDs	OMIM: 603699; MGI: 101948; HomoloGene: 20970; GeneCards: WNT11; OMA:WNT11 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	76,210,736 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	98,504,402 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; subcutaneous adipose tissue; ; right adrenal cortex; ; left adrenal cortex; ; testicle; ; right lobe of thyroid gland; ; apex of heart; ; gastrocnemius muscle; ; left lobe of thyroid gland; ; tendon;
	Top expressed in
	lip; ; muscle layer of urethra; ; mucous cell of stomach; ; muscle layer of ejaculatory duct; ; muscle of thigh; ; muscle layer of seminal vesicle; ; pyloric antrum; ; external carotid artery; ; hair; ; right ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity; frizzled binding; protein kinase activator activity; protein binding; signaling receptor binding;
Cellular component	extracellular region; extracellular space; cytoplasm; extracellular matrix;
Biological process	ureteric bud morphogenesis; cellular response to retinoic acid; bone mineralization; cell differentiation; non-canonical Wnt signaling pathway; cell fate commitment; negative regulation of cartilage development; paraxial mesoderm formation; mesonephric duct development; convergent extension involved in axis elongation; positive regulation of protein kinase C signaling; kidney development; positive regulation of cell migration; ventricular septum morphogenesis; outflow tract morphogenesis; negative regulation of apoptotic process; negative regulation of cell death; adrenal gland development; planar cell polarity pathway involved in axis elongation; positive regulation of transforming growth factor beta2 production; somite development; embryonic skeletal system development; positive regulation of transcription, DNA-templated; multicellular organism development; protein phosphorylation; positive regulation of GTPase activity; maintenance of epithelial cell apical/basal polarity; positive regulation of gene expression; Wnt signaling pathway, calcium modulating pathway; negative regulation of cell migration; response to nutrient levels; protein localization to cell surface; notochord morphogenesis; negative regulation of cell growth; osteoblast differentiation; neuron differentiation; artery morphogenesis; bicellular tight junction assembly; epithelial to mesenchymal transition; positive regulation of apoptotic process; canonical Wnt signaling pathway; lung-associated mesenchyme development; negative regulation of transcription, DNA-templated; cloacal septation; negative regulation of mesenchymal cell proliferation; neuroendocrine cell differentiation; negative regulation of canonical Wnt signaling pathway; negative regulation of fibroblast growth factor production; positive regulation of stress fiber assembly; planar cell polarity pathway involved in gastrula mediolateral intercalation; Wnt signaling pathway, planar cell polarity pathway; Wnt signaling pathway; activation of protein kinase activity; cellular response to mechanical stimulus; roof of mouth development; secondary palate development;
	Sources:Amigo / QuickGO
Orthologs
	7481
	22411
	ENSG00000085741
	ENSMUSG00000015957
	O96014
	P48615
	NM_004626
	NM_001285792; NM_001285794; NM_001285795; NM_009519
	NP_004617
	NP_001272721; NP_001272723; NP_001272724; NP_033545
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Wnt-11 is a protein that in humans is encoded by the WNT11 gene.⁵⁶

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene plays roles in the development of bones, kidneys,⁷ and lungs,⁵ and is associated with early onset osteoporosis. ⁸

References

GRCh38: Ensembl release 89: ENSG00000085741 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000015957 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lako M, Strachan T, Bullen P, Wilson DI, Robson SC, Lindsay S (December 1998). "Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung". Gene. 219 (1–2): 101–110. doi:10.1016/S0378-1119(98)00393-X. PMID 9757009.
"Entrez Gene: WNT11 wingless-type MMTV integration site family, member 11".
Majumdar A, Vainio S, Kispert A, McMahon J, McMahon AP (July 2003). "Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development". Development. 130 (14). Cambridge, England: The Company of Biologists: 3175–3185. doi:10.1242/dev.00520. PMID 12783789. S2CID 25866889.
Caetano da Silva C, Edouard T, Fradin M, Aubert-Mucca M, Ricquebourg M, Raman R, et al. (May 2022). "WNT11, a new gene associated with early onset osteoporosis, is required for osteoblastogenesis". Human Molecular Genetics. 31 (10). Oxford University Press (OUP): 1622–1634. doi:10.1093/hmg/ddab349. PMC 9122655. PMID 34875064.

Further reading

Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Molecular Biology of the Cell. 4 (12): 1267–1275. doi:10.1091/mbc.4.12.1267. PMC 275763. PMID 8167409.
Kirikoshi H, Sekihara H, Katoh M (2002). "Molecular cloning and characterization of human WNT11". International Journal of Molecular Medicine. 8 (6): 651–656. doi:10.3892/ijmm.8.6.651. PMID 11712081.
Ouko L, Ziegler TR, Gu LH, Eisenberg LM, Yang VW (June 2004). "Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells". The Journal of Biological Chemistry. 279 (25): 26707–26715. doi:10.1074/jbc.M402877200. PMC 1351009. PMID 15084607.
Kim SW, Park JI, Spring CM, Sater AK, Ji H, Otchere AA, et al. (December 2004). "Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin". Nature Cell Biology. 6 (12): 1212–1220. doi:10.1038/ncb1191. PMID 15543138. S2CID 19404686.
Koyanagi M, Haendeler J, Badorff C, Brandes RP, Hoffmann J, Pandur P, et al. (April 2005). "Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells". The Journal of Biological Chemistry. 280 (17): 16838–16842. doi:10.1074/jbc.M500323200. PMID 15701629.
Garriock RJ, D'Agostino SL, Pilcher KC, Krieg PA (2005). "Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus". Developmental Biology. 279 (1): 179–192. doi:10.1016/j.ydbio.2004.12.013. PMID 15708567.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2005). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–126. doi:10.1093/dnares/12.2.117. PMID 16303743.
Panáková D, Werdich AA, Macrae CA (2010). "Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel". Nature. 466 (8): 874–878. Bibcode:2010Natur.466..874P. doi:10.1038/nature09249. PMC 2921013. PMID 20657579.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000085741 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015957 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Lako_1998-5] Lako M, Strachan T, Bullen P, Wilson DI, Robson SC, Lindsay S (December 1998). "Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung". Gene. 219 (1–2): 101–110. doi:10.1016/S0378-1119(98)00393-X. PMID 9757009.

[entrez-6] "Entrez Gene: WNT11 wingless-type MMTV integration site family, member 11".

[Majumdar_Vainio_Kispert_McMahon_2003_pp._3175–3185-7] Majumdar A, Vainio S, Kispert A, McMahon J, McMahon AP (July 2003). "Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development". Development. 130 (14). Cambridge, England: The Company of Biologists: 3175–3185. doi:10.1242/dev.00520. PMID 12783789. S2CID 25866889.

[Caetano_da_Silva_Edouard_Fradin_Aubert-Mucca_2021_pp._1622–1634-8] Caetano da Silva C, Edouard T, Fradin M, Aubert-Mucca M, Ricquebourg M, Raman R, et al. (May 2022). "WNT11, a new gene associated with early onset osteoporosis, is required for osteoblastogenesis". Human Molecular Genetics. 31 (10). Oxford University Press (OUP): 1622–1634. doi:10.1093/hmg/ddab349. PMC 9122655. PMID 34875064.

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