WNT10B

WNT10B
Identifiers
Aliases	WNT10B, SHFM6, WNT-12, Wnt family member 10B, STHAG8
External IDs	OMIM: 601906; MGI: 108061; HomoloGene: 20721; GeneCards: WNT10B; OMA:WNT10B - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	48,971,735 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	98,676,031 bp
RNA expression pattern
	Top expressed in
	orbitofrontal cortex; ; nucleus accumbens; ; Brodmann area 10; ; Region I of hippocampus proper; ; cingulate gyrus; ; anterior cingulate cortex; ; Brodmann area 46; ; right frontal lobe; ; dorsolateral prefrontal cortex; ; entorhinal cortex;
	Top expressed in
	prostatic epithelium; ; surface ectoderm; ; inner root sheath; ; enamel knot; ; hair; ; skin of finger; ; lip; ; inner cell mass; ; morula; ; pretectal area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	receptor ligand activity; frizzled binding; signaling receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	cellular response to organic substance; myoblast differentiation involved in skeletal muscle regeneration; cellular response to retinoic acid; cell fate commitment; negative regulation of fat cell differentiation; positive regulation of RNA polymerase II transcription preinitiation complex assembly; chondrocyte differentiation; positive regulation of bone mineralization; lipid metabolism; positive regulation of canonical Wnt signaling pathway; regulation of transcription by RNA polymerase II; hematopoietic stem cell proliferation; cellular response to organic cyclic compound; protein stabilization; positive regulation of DNA-binding transcription factor activity; positive regulation of ossification; negative regulation of transcription by RNA polymerase II; bone trabecula formation; positive regulation of timing of anagen; regulation of fat cell differentiation; multicellular organism development; positive regulation of epithelial cell differentiation; positive regulation of osteoblast differentiation; fungiform papilla development; skeletal muscle tissue regeneration; G2/M transition of mitotic cell cycle; skeletal muscle fiber development; neuron differentiation; positive regulation of cell population proliferation; negative regulation of epithelial cell proliferation; positive regulation of apoptotic process; regulation of proteasomal ubiquitin-dependent protein catabolic process; canonical Wnt signaling pathway; regulation of skeletal muscle tissue development; positive regulation of G2/M transition of mitotic cell cycle; smoothened signaling pathway; cellular response to parathyroid hormone stimulus; regulation of protein metabolic process; sensory perception of taste; cellular response to cAMP; positive regulation of transcription by RNA polymerase II; Wnt signaling pathway; regulation of signaling receptor activity; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	7480
	22410
	ENSG00000169884
	ENSMUSG00000022996
	O00744
	P48614
	NM_003394
	NM_011718
	NP_003385
	NP_035848
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Wnt-10b (formerly Wnt12⁵) is a protein that in humans is encoded by the WNT10B gene.⁶⁷⁸⁹

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis.

This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is, it is presumed, a molecular switch that governs adipogenesis. Gain-of-function of Wnt10b in mouse hearts has shown to improve cardiac tissue repair after myocardial injury, by promoting coronary vessel formation and attenuating pathological fibrosis.¹⁰ This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region.⁹

A study published in August 2025 revealed another role of Wnt10b: it helps cancer cells resist stress. When a tumor cell divides too quickly, its DNA is at risk. Wnt10b acts as a stabilizer: it prevents the internal filaments (microtubules) from going at a too intense rate, avoiding improper chromosome segregation. As a result, the cancer cell survives.¹¹

Chromosomal instability can drive dangerous tumor evolution, Wnt10b pathway is actively implicated in limiting the instability. Cancer cells use this pathway as a shield to survive the instability they create, preventing an excessive DNA damage and division errors. This makes Wnt10b a potential target for new cancer therapies. Wnt10b inhibition combined with chemotherapy could therefore become a new therapeutic strategy.¹²

References

GRCh38: Ensembl release 89: ENSG00000169884 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022996 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Schubert M, Holland LZ, Holland ND, Jacobs DK (2000). "A phylogenetic tree of the Wnt genes based on all available full-length sequences, including five from the cephalochordate amphioxus". Molecular Biology and Evolution. 17 (12): 1896–903. doi:10.1093/oxfordjournals.molbev.a026291. PMID 11110906.
Bui TD, Rankin J, Smith K, Huguet EL, Ruben S, Strachan T, Harris AL, Lindsay S (Apr 1997). "A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas". Oncogene. 14 (10): 1249–53. doi:10.1038/sj.onc.1200936. PMID 9121776.
Hardiman G, Kastelein RA, Bazan JF (Sep 1997). "Isolation, characterization and chromosomal localization of human WNT10B". Cytogenet Cell Genet. 77 (3–4): 278–82. doi:10.1159/000134597. PMID 9284937.
Ugur SA, Tolun A (Aug 2008). "Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation". Hum Mol Genet. 17 (17): 2644–53. doi:10.1093/hmg/ddn164. PMID 18515319.
"Entrez Gene: WNT10B wingless-type MMTV integration site family, member 10B".
Paik DT, Rai M, Ryzhov S, Sanders LN, Aisagbonhi O, Funke MJ, Feoktistov I, Hatzopoulos AK. Wnt10b gain-of-function improves cardiac repair by arteriole formation and attenuation of fibrosis. Circ Res. 2015; 117:804-816.
Haas, Alexander; Wenz, Friederike; Hattemer, Janina; Wesslowski, Janine; Davidson, Gary; Voloshanenko, Oksana; Boutros, Michael; Acebron, Sergio P.; Bastians, Holger (November 2025). "Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer". Life Science Alliance. 8 (11): e202503295. doi:10.26508/lsa.202503295. ISSN 2575-1077. PMC 12373720. PMID 40846632.{{cite journal}}: CS1 maint: article number as page number (link)
Cite error: The named reference ah was invoked but never defined (see the help page).

Further reading

Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC 275763. PMID 8167409.
Bergstein I, Eisenberg LM, Bhalerao J, et al. (1998). "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21". Genomics. 46 (3): 450–8. doi:10.1006/geno.1997.5041. PMID 9441749.
Ross SE, Hemati N, Longo KA, et al. (2000). "Inhibition of adipogenesis by Wnt signaling". Science. 289 (5481): 950–3. Bibcode:2000Sci...289..950R. doi:10.1126/science.289.5481.950. PMID 10937998.
Kirikoshi H, Sekihara H, Katoh M (2001). "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells". Biochem. Biophys. Res. Commun. 283 (4): 798–805. doi:10.1006/bbrc.2001.4855. PMID 11350055.
Saitoh T, Kirikoshi H, Mine T, Katoh M (2002). "Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45". Int. J. Oncol. 19 (6): 1187–92. doi:10.3892/ijo.19.6.1187. PMID 11713588.
Kasat K, Go V, Pogo BG (2003). "Effects of pyrethroid insecticides and estrogen on WNT10B proto-oncogene expression". Environment International. 28 (5): 429–32. doi:10.1016/S0160-4120(02)00072-7. PMID 12437293.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Christodoulides C, Scarda A, Granzotto M, et al. (2006). "WNT10B mutations in human obesity". Diabetologia. 49 (4): 678–84. doi:10.1007/s00125-006-0144-4. PMC 4304000. PMID 16477437.
Thrasivoulou C, Millar M, Ahmed A (2013). "Activation of intracellular calcium by multiple Wnt ligands and translocation of β-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/β-catenin pathways". J. Biol. Chem. 288 (50): 35651–35659. doi:10.1074/jbc.M112.437913. PMC 3861617. PMID 24158438.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169884 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022996 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Schubert M, Holland LZ, Holland ND, Jacobs DK (2000). "A phylogenetic tree of the Wnt genes based on all available full-length sequences, including five from the cephalochordate amphioxus". Molecular Biology and Evolution. 17 (12): 1896–903. doi:10.1093/oxfordjournals.molbev.a026291. PMID 11110906.

[pmid9121776-6] Bui TD, Rankin J, Smith K, Huguet EL, Ruben S, Strachan T, Harris AL, Lindsay S (Apr 1997). "A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas". Oncogene. 14 (10): 1249–53. doi:10.1038/sj.onc.1200936. PMID 9121776.

[pmid9284937-7] Hardiman G, Kastelein RA, Bazan JF (Sep 1997). "Isolation, characterization and chromosomal localization of human WNT10B". Cytogenet Cell Genet. 77 (3–4): 278–82. doi:10.1159/000134597. PMID 9284937.

[pmid18515319-8] Ugur SA, Tolun A (Aug 2008). "Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation". Hum Mol Genet. 17 (17): 2644–53. doi:10.1093/hmg/ddn164. PMID 18515319.

[entrez-9] "Entrez Gene: WNT10B wingless-type MMTV integration site family, member 10B".

[10] Paik DT, Rai M, Ryzhov S, Sanders LN, Aisagbonhi O, Funke MJ, Feoktistov I, Hatzopoulos AK. Wnt10b gain-of-function improves cardiac repair by arteriole formation and attenuation of fibrosis. Circ Res. 2015; 117:804-816.

[11] Haas, Alexander; Wenz, Friederike; Hattemer, Janina; Wesslowski, Janine; Davidson, Gary; Voloshanenko, Oksana; Boutros, Michael; Acebron, Sergio P.; Bastians, Holger (November 2025). "Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer". Life Science Alliance. 8 (11): e202503295. doi:10.26508/lsa.202503295. ISSN 2575-1077. PMC 12373720. PMID 40846632.{{cite journal}}: CS1 maint: article number as page number (link)

[ah-12] Cite error: The named reference ah was invoked but never defined (see the help page).

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