USP22

USP22
Identifiers
Aliases	USP22, USP3L, ubiquitin specific peptidase 22
External IDs	OMIM: 612116; MGI: 2144157; HomoloGene: 52664; GeneCards: USP22; OMA:USP22 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	21,043,760 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	61,065,881 bp
RNA expression pattern
	Top expressed in
	paraflocculus of cerebellum; ; ganglionic eminence; ; middle frontal gyrus; ; frontal pole; ; stromal cell of endometrium; ; Brodmann area 10; ; ventricular zone; ; right hemisphere of cerebellum; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	ganglionic eminence; ; medial ganglionic eminence; ; paraventricular nucleus of hypothalamus; ; arcuate nucleus; ; dentate gyrus of hippocampal formation granule cell; ; dorsomedial hypothalamic nucleus; ; ventromedial nucleus; ; medial geniculate nucleus; ; anterior amygdaloid area; ; subiculum;
	More reference expression data
	n/a
Gene ontology
Molecular function	cysteine-type peptidase activity; transcription coactivator activity; zinc ion binding; H4 histone acetyltransferase activity; metal ion binding; peptidase activity; protein binding; nuclear receptor coactivator activity; thiol-dependent deubiquitinase; enzyme binding; hydrolase activity;
Cellular component	SAGA-type complex; SAGA complex; nucleus; nucleoplasm; nuclear speck;
Biological process	regulation of transcription, DNA-templated; ubiquitin-dependent protein catabolic process; positive regulation of mitotic cell cycle; transcription, DNA-templated; proteolysis; positive regulation of transcription, DNA-templated; histone deubiquitination; cell cycle; histone ubiquitination; histone H4 acetylation; protein deubiquitination; embryo development ending in birth or egg hatching; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	23326
	216825
	ENSG00000124422
	ENSMUSG00000042506
	Q9UPT9
	Q5DU02
	NM_015276
	NM_001004143
	NP_056091
	NP_001004143
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin specific peptidase 22 is a protein that in humans is encoded by the USP22 gene on chromosome 17.⁵ USP22 is known to function as a histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA.⁶

References

GRCh38: Ensembl release 89: ENSG00000124422 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000042506 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Ubiquitin specific peptidase 22".
"Q9UPT9 (UBP22_HUMAN)". UniProt.

Further reading

Lang G, Bonnet J, Umlauf D, Karmodiya K, Koffler J, Stierle M, Devys D, Tora L (September 2011). "The tightly controlled deubiquitination activity of the human SAGA complex differentially modifies distinct gene regulatory elements". Molecular and Cellular Biology. 31 (18): 3734–44. doi:10.1128/MCB.05231-11. PMC 3165722. PMID 21746879.
Wang YL, Faiola F, Xu M, Pan S, Martinez E (December 2008). "Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein". The Journal of Biological Chemistry. 283 (49): 33808–15. doi:10.1074/jbc.M806936200. PMC 2590711. PMID 18838386.
Armour SM, Bennett EJ, Braun CR, Zhang XY, McMahon SB, Gygi SP, Harper JW, Sinclair DA (April 2013). "A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex". Molecular and Cellular Biology. 33 (8): 1487–502. doi:10.1128/MCB.00971-12. PMC 3624249. PMID 23382074.
Zhang Y, Yao L, Zhang X, Ji H, Wang L, Sun S, Pang D (August 2011). "Elevated expression of USP22 in correlation with poor prognosis in patients with invasive breast cancer". Journal of Cancer Research and Clinical Oncology. 137 (8): 1245–53. doi:10.1007/s00432-011-0998-9. PMC 11827975. PMID 21691749. S2CID 9026376.
Ling SB, Sun DG, Tang B, Guo C, Zhang Y, Liang R, Wang LM (December 2012). "Knock-down of USP22 by small interfering RNA interference inhibits HepG2 cell proliferation and induces cell cycle arrest". Cellular and Molecular Biology. 58 Suppl: OL1803-8. PMID 23217440.
Xiong J, Che X, Li X, Yu H, Gong Z, Li W (2012). Semsey S (ed.). "Cloning and characterization of the human USP22 gene promoter". PLOS ONE. 7 (12) e52716. Bibcode:2012PLoSO...752716X. doi:10.1371/journal.pone.0052716. PMC 3530469. PMID 23300749.
Glinsky GV, Berezovska O, Glinskii AB (June 2005). "Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer". The Journal of Clinical Investigation. 115 (6): 1503–21. doi:10.1172/JCI23412. PMC 1136989. PMID 15931389.
Xu H, Liu YL, Yang YM, Dong XS (January 2012). "Knock-down of ubiquitin-specific protease 22 by micro-RNA interference inhibits colorectal cancer growth". International Journal of Colorectal Disease. 27 (1): 21–30. doi:10.1007/s00384-011-1275-8. PMID 21773699. S2CID 25987858.
Liu YL, Yang YM, Xu H, Dong XS (March 2011). "Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer". Journal of Surgical Oncology. 103 (3): 283–9. doi:10.1002/jso.21802. PMID 21337558. S2CID 30706374.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124422 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042506 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Ubiquitin specific peptidase 22".

[6] "Q9UPT9 (UBP22_HUMAN)". UniProt.

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