Article · Wikipedia archive · Last revised Jul 30, 2026

U-92016-A

U-92,016-A is a potent, high efficacy, and selective serotonin 5-HT1A receptor full agonist with a long duration of action. It has been suggested that it could be developed as an anxiolytic or antidepressant.

Last revised
Jul 30, 2026
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≈ 1 min
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Wikipedia ↗
U-92016-A
Clinical data
Other namesU-92016A; U-92016-A; U92016A; U92016-A; U-92,016-A
Drug classSerotonin 5-HT1A receptor agonist
Identifiers
  • (8R)-8-(Dipropylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-2-carbonitrile
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H25N3
Molar mass295.430 g·mol−1
3D model (JSmol)
  • N#Cc3cc1c(ccc2c1C[C@H](N(CCC)CCC)CC2)[nH]3
  • InChI=1S/C19H25N3/c1-3-9-22(10-4-2)16-7-5-14-6-8-19-18(17(14)12-16)11-15(13-20)21-19/h6,8,11,16,21H,3-5,7,9-10,12H2,1-2H3/t16-/m1/s1 checkY
  • Key:WDDZPZKGLZNGEH-MRXNPFEDSA-N checkY
  (verify)

U-92016A, or U92016A, is a potent, high efficacy, and selective serotonin 5-HT1A receptor full agonist with a long duration of action.12 It has been suggested that it could be developed as an anxiolytic or antidepressant.1

See also

See also

References

References

  1. Romero AG, Leiby JA, McCall RB, Piercey MF, Smith MW, Han F (1993). "Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants". J Med Chem. 36 (15): 2066–2074. doi:10.1021/jm00067a003. PMID 8101876.
  2. McCall RB, Romero AG, Bienkowski MJ, Harris DW, McGuire JC, Piercey MF, Shuck ME, Smith MW, Svensson KA, Schreur PJ, et al. (1994). "Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist". J Pharmacol Exp Ther. 271 (2): 875–883. doi:10.1016/S0022-3565(25)23851-4. PMID 7965808.