Article · Wikipedia archive · Last revised Jun 4, 2026

TTK (gene)

Dual specificity protein kinase TTK also known as Mps1 is an enzyme that in humans is encoded by the TTK gene.

Last revised

Jun 4, 2026

Read time

≈ 4 min

Length

940 w

Citations

10

Source

TTK

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2X9E, 2ZMC, 2ZMD, 3CEK, 3DBQ, 3GFW, 3H9F, 3HMN, 3HMO, 3HMP, 3VQU, 3W1F, 3WYX, 3WYY, 3WZJ, 3WZK, 4B94, 4BHZ, 4BI0, 4BI1, 4BI2, 4C4E, 4C4G, 4C4H, 4C4I, 4C4J, 4CV8, 4CV9, 4CVA, 4D2S, 4H7X, 4H7Y, 4JS8, 4JT3, 4O6L, 5AP0, 5AP1, 5AP2, 5AP3, 5AP4, 5AP5, 5AP6, 5AP7, 5EI2, 5EHY, 5EH0, 5EI6, 4ZEG, 5EI8

Identifiers

TTK, CT96, ESK, MPH1, MPS1, MPS1L1, PYT, TTK protein kinase

External IDs

OMIM: 604092; MGI: 1194921; HomoloGene: 2489; GeneCards: TTK; OMA:TTK - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)¹

Band	6q14.1	Start	80,003,887 bp¹
Band	6q14.1	End	80,042,527 bp¹

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)²

Band	9\|9 E2	Start	83,716,742 bp²
Band	9\|9 E2	End	83,754,442 bp²

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

ventricular zone

gonad

testicle

ganglionic eminence

sperm

trabecular bone

right testis

left testis

bone marrow

Top expressed in

zygote

primary oocyte

genital tubercle

tail of embryo

maxillary prominence

secondary oocyte

mandibular prominence

epiblast

spermatocyte

spermatid

More reference expression data


More reference expression data

Gene ontology
Molecular function	kinase activity transferase activity protein serine/threonine/tyrosine kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity nucleotide binding protein kinase activity protein binding ATP binding protein homodimerization activity kinetochore binding
Cellular component	spindle membrane cytoplasm kinetochore nucleus
Biological process	chromosome separation mitotic spindle organization positive regulation of pathway-restricted SMAD protein phosphorylation spindle organization mitotic spindle assembly checkpoint signaling positive regulation of cell population proliferation protein phosphorylation phosphorylation mitotic cell cycle checkpoint signaling peptidyl-tyrosine phosphorylation female meiosis chromosome segregation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation meiotic spindle assembly checkpoint signaling protein localization to kinetochore protein localization to chromosome protein autophosphorylation protein localization to meiotic spindle midzone chromosome segregation
Sources:Amigo / QuickGO

Species

Human

Mouse


7272


22137


ENSG00000112742


ENSMUSG00000038379


P33981


P35761

RefSeq (mRNA)


NM_001166691 NM_003318


NM_001110265 NM_001284272 NM_009445

RefSeq (protein)


NP_001160163 NP_003309


NP_001103735 NP_001271201 NP_033471

Location (UCSC)

Chr 6: 80 – 80.04 Mb

Chr 9: 83.72 – 83.75 Mb

PubMed search

³

⁴

View/Edit Human

View/Edit Mouse

Dual specificity protein kinase TTK also known as Mps1 is an enzyme that in humans is encoded by the TTK gene.⁵⁶

References

References

GRCh38: Ensembl release 89: ENSG00000112742 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038379 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Mills GB, Schmandt R, McGill M, Amendola A, Hill M, Jacobs K, May C, Rodricks AM, Campbell S, Hogg D (Aug 1992). "Expression of TTK, a novel human protein kinase, is associated with cell proliferation". J Biol Chem. 267 (22): 16000–6. doi:10.1016/S0021-9258(19)49633-6. PMID 1639825.
"Entrez Gene: TTK TTK protein kinase".

Further reading

Further reading

Hanks SK, Quinn AM (1991). "Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members". Protein Phosphorylation Part A: Protein Kinases: Assays, Purification, Antibodies, Functional Analysis, Cloning, and Expression. Methods in Enzymology. Vol. 200. pp. 38–62. doi:10.1016/0076-6879(91)00126-H. ISBN 978-0-12-182101-2. PMID 1956325.
Lindberg RA, Fischer WH, Hunter T (1993). "Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine". Oncogene. 8 (2): 351–9. PMID 7678926.
Lauzé E, Stoelcker B, Luca FC, et al. (1995). "Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase". EMBO J. 14 (8): 1655–63. doi:10.1002/j.1460-2075.1995.tb07154.x. PMC 398258. PMID 7737118.
Cahill DP, da Costa LT, Carson-Walter EB, et al. (1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes". Genomics. 58 (2): 181–7. doi:10.1006/geno.1999.5831. PMID 10366450.
Weinmann AS, Yan PS, Oberley MJ, et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMC 155318. PMID 11799066.
Stucke VM, Silljé HH, Arnaud L, Nigg EA (2002). "Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication". EMBO J. 21 (7): 1723–32. doi:10.1093/emboj/21.7.1723. PMC 125937. PMID 11927556.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Liu ST, Chan GK, Hittle JC, et al. (2003). "Human MPS1 Kinase Is Required for Mitotic Arrest Induced by the Loss of CENP-E from Kinetochores". Mol. Biol. Cell. 14 (4): 1638–51. doi:10.1091/mbc.02-05-0074. PMC 153128. PMID 12686615.
Fisk HA, Mattison CP, Winey M (2004). "Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression". Proc. Natl. Acad. Sci. U.S.A. 100 (25): 14875–80. doi:10.1073/pnas.2434156100. PMC 299837. PMID 14657364.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dou Z, Ding X, Zereshki A, et al. (2004). "TTK kinase is essential for the centrosomal localization of TACC2". FEBS Lett. 572 (1–3): 51–6. Bibcode:2004FEBSL.572...51D. doi:10.1016/j.febslet.2004.06.092. PMID 15304323. S2CID 8403635.
Wei JH, Chou YF, Ou YH, et al. (2005). "TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68". J. Biol. Chem. 280 (9): 7748–57. doi:10.1074/jbc.M410152200. PMID 15618221.
Camacho E, Beà S, Salaverría I, et al. (2006). "Analysis of Aurora-A and hMPS1 mitotic kinases in mantle cell lymphoma". Int. J. Cancer. 118 (2): 357–63. doi:10.1002/ijc.21370. PMID 16080195. S2CID 7968793.
Leng M, Chan DW, Luo H, et al. (2006). "MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability". Proc. Natl. Acad. Sci. U.S.A. 103 (31): 11485–90. Bibcode:2006PNAS..10311485L. doi:10.1073/pnas.0601828103. PMC 1518802. PMID 16864798.
Bertheau P, Turpin E, Rickman DS, et al. (2007). "Exquisite Sensitivity of TP53 Mutant and Basal Breast Cancers to a Dose-Dense Epirubicin−Cyclophosphamide Regimen". PLOS Med. 4 (3): e90. doi:10.1371/journal.pmed.0040090. PMC 1831731. PMID 17388661.
Zhu S, Wang W, Clarke DC, Liu X (2007). "Activation of Mps1 promotes transforming growth factor-beta-independent Smad signaling". J. Biol. Chem. 282 (25): 18327–38. doi:10.1074/jbc.M700636200. PMID 17452325.
Kanai M, Ma Z, Izumi H, et al. (2007). "Physical and functional interaction between mortalin and Mps1 kinase". Genes Cells. 12 (6): 797–810. doi:10.1111/j.1365-2443.2007.01091.x. PMID 17573779. S2CID 342866.
Mattison CP, Old WM, Steiner E, et al. (2007). "Mps1 activation loop autophosphorylation enhances kinase activity". J. Biol. Chem. 282 (42): 30553–61. doi:10.1074/jbc.M707063200. PMID 17728254.