TSHB

TSHB
Identifiers
Aliases	TSHB, TSH-B, TSH-BETA, thyroid stimulating hormone beta, Thyroid stimulating hormone, beta, thyroid stimulating hormone subunit beta
External IDs	OMIM: 188540; MGI: 98848; HomoloGene: 463; GeneCards: TSHB; OMA:TSHB - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	115,034,302 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	102,690,034 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; testicle; ; buccal mucosa cell; ; tibialis anterior muscle; ; tibial arteries; ; gastric mucosa; ; islet of Langerhans; ; Descending thoracic aorta; ; body of uterus; ; Achilles tendon;
	Top expressed in
	pituitary gland; ; median eminence; ; anterior pituitary; ; arcuate nucleus; ; left lung lobe; ; embryo; ; pars tuberalis; ; granulocyte; ; pars distalis of adenohypophysis; ; ascending aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	hormone activity;
Cellular component	extracellular region; extracellular space; cytoplasm;
Biological process	response to calcium ion; cell-cell signaling; anatomical structure morphogenesis; G protein-coupled receptor signaling pathway; response to vitamin A; peptide hormone processing; response to estrogen; hormone-mediated signaling pathway; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	7252
	22094
	ENSG00000134200
	ENSMUSG00000027857
	P01222
	P12656
	NM_000549; NM_001277991
	NM_001165939; NM_001165940; NM_009432
	NP_000540; NP_001264920
	NP_001159411; NP_001159412; NP_033458
	Wikidata
View/Edit Human	View/Edit Mouse

Thyroid stimulating hormone, beta also known as TSHB is a protein which in humans is encoded by the TSHB gene.⁵⁶

Function

Thyrotropin-stimulating hormone (TSH) is a noncovalently linked glycoprotein heterodimer and is part of a family of pituitary hormones containing a common alpha subunit (TSHA) and a unique beta subunit (this protein) that confers specificity.⁷

References

GRCh38: Ensembl release 89: ENSG00000134200 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027857 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wondisford FE, Radovick S, Moates JM, Usala SJ, Weintraub BD (September 1988). "Isolation and characterization of the human thyrotropin beta-subunit gene. Differences in gene structure and promoter function from murine species". J. Biol. Chem. 263 (25): 12538–42. doi:10.1016/S0021-9258(18)37788-3. PMID 2457586.
Tatsumi K, Hayashizaki Y, Hiraoka Y, Miyai K, Matsubara K (December 1988). "The structure of the human thyrotropin beta-subunit gene". Gene. 73 (2): 489–97. doi:10.1016/0378-1119(88)90513-6. PMID 3243440.
"Entrez Gene: TSHB".

Further reading

Bonomi M, Proverbio MC, Weber G, et al. (2001). "Hyperplastic pituitary gland, high serum glycoprotein hormone alpha-subunit, and variable circulating thyrotropin (TSH) levels as hallmark of central hypothyroidism due to mutations of the TSH beta gene". J. Clin. Endocrinol. Metab. 86 (4): 1600–4. doi:10.1210/jcem.86.4.7411. PMID 11297590.
Vuissoz JM, Deladoëy J, Buyukgebiz A, et al. (2001). "New autosomal recessive mutation of the TSH-beta subunit gene causing central isolated hypothyroidism". J. Clin. Endocrinol. Metab. 86 (9): 4468–71. doi:10.1210/jcem.86.9.7876. PMID 11549695.
Karges B, LeHeup B, Schoenle E, et al. (2004). "Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in Europe". Horm. Res. 62 (3): 149–55. doi:10.1159/000080071. PMID 15297803. S2CID 28309388.
Kabadi UM, Premachandra BN (2007). "Serum thyrotropin in Graves' disease: a more reliable index of circulating thyroid-stimulating immunoglobulin level than thyroid function?". Endocr Pract. 13 (6): 615–9. doi:10.4158/ep.13.6.615. PMID 17954417.
Miyai S, Yoshimura S, Iwasaki Y, et al. (2005). "Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line". Cell Tissue Res. 322 (2): 269–77. doi:10.1007/s00441-005-0033-z. PMID 16133148. S2CID 37186810.
Pierce JG (1971). "Eli Lilly lecture. The subunits of pituitary thyrotropin--their relationship to other glycoprotein hormones". Endocrinology. 89 (6): 1331–44. doi:10.1210/endo-89-6-1331. PMID 5002675.
Atzmon G, Barzilai N, Surks MI, Gabriely I (2009). "Genetic Predisposition to Elevated Serum Thyrotropin Is Associated with Exceptional Longevity". J. Clin. Endocrinol. Metab. 94 (12): 4768–75. doi:10.1210/jc.2009-0808. PMC 2795660. PMID 19837933.
Landa I, Ruiz-Llorente S, Montero-Conde C, et al. (2009). Gibson G (ed.). "The Variant rs1867277 in FOXE1 Gene Confers Thyroid Cancer Susceptibility through the Recruitment of USF1/USF2 Transcription Factors". PLOS Genet. 5 (9) e1000637. doi:10.1371/journal.pgen.1000637. PMC 2727793. PMID 19730683.
Pohlenz J, Dumitrescu A, Aumann U, et al. (2002). "Congenital secondary hypothyroidism caused by exon skipping due to a homozygous donor splice site mutation in the TSHbeta-subunit gene". J. Clin. Endocrinol. Metab. 87 (1): 336–9. doi:10.1210/jcem.87.1.8154. PMID 11788671.
Miyoshi I, Kasai N, Hayashizaki Y (1994). "[Structure and regulation of human thyroid-stimulating hormone (TSH) gene]". Nippon Rinsho. 52 (4): 940–7. PMID 8196184.
Borck G, Topaloglu AK, Korsch E, et al. (2004). "Four new cases of congenital secondary hypothyroidism due to a splice site mutation in the thyrotropin-beta gene: phenotypic variability and founder effect". J. Clin. Endocrinol. Metab. 89 (8): 4136–41. doi:10.1210/jc.2004-0494. PMID 15292359.
Comings DE, Gade-Andavolu R, Gonzalez N, et al. (2000). "A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory". Clin. Genet. 58 (5): 375–85. doi:10.1034/j.1399-0004.2000.580508.x. PMID 11140838. S2CID 14733771.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Clark AG, Glanowski S, Nielsen R, et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios". Science. 302 (5652): 1960–3. Bibcode:2003Sci...302.1960C. doi:10.1126/science.1088821. PMID 14671302. S2CID 6682593.
Loinder K, Söderström M (2005). "An LXXLL motif in nuclear receptor corepressor mediates ligand-induced repression of the thyroid stimulating hormone-beta gene". J. Steroid Biochem. Mol. Biol. 97 (4): 322–7. doi:10.1016/j.jsbmb.2005.06.031. PMID 16216492. S2CID 45326566.
Luttrell LM (2008). "Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors". Mol. Biotechnol. 39 (3): 239–64. doi:10.1007/s12033-008-9031-1. PMID 18240029. S2CID 45173229.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brumm H, Pfeufer A, Biebermann H, et al. (2002). "Congenital central hypothyroidism due to homozygous thyrotropin beta 313 Delta T mutation is caused by a Founder effect". J. Clin. Endocrinol. Metab. 87 (10): 4811–6. doi:10.1210/jc.2002-020297. PMID 12364478.
Benhadi N, Wiersinga WM, Reitsma JB, et al. (2009). "Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death". Eur. J. Endocrinol. 160 (6): 985–91. doi:10.1530/EJE-08-0953. PMID 19273570.
Schaefer JS, Klein JR (2009). "A novel thyroid stimulating hormone β-subunit isoform in human pituitary, peripheral blood leukocytes, and thyroid". Gen. Comp. Endocrinol. 162 (3): 241–4. doi:10.1016/j.ygcen.2009.04.006. PMC 2689139. PMID 19364510.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134200 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027857 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2457586-5] Wondisford FE, Radovick S, Moates JM, Usala SJ, Weintraub BD (September 1988). "Isolation and characterization of the human thyrotropin beta-subunit gene. Differences in gene structure and promoter function from murine species". J. Biol. Chem. 263 (25): 12538–42. doi:10.1016/S0021-9258(18)37788-3. PMID 2457586.

[pmid3243440-6] Tatsumi K, Hayashizaki Y, Hiraoka Y, Miyai K, Matsubara K (December 1988). "The structure of the human thyrotropin beta-subunit gene". Gene. 73 (2): 489–97. doi:10.1016/0378-1119(88)90513-6. PMID 3243440.

[entrez-7] "Entrez Gene: TSHB".

1

2

3

4

5

6

7

Function

See also

References

Further reading