Article · Wikipedia archive · Last revised Jun 22, 2026

Trofosfamide

Trofosfamide (INN) is a nitrogen mustard alkylating agent. It is sometimes abbreviated "TRO". It has been used in trials to study its effects on ependymoma, medulloblastoma, sarcoma, soft tissue, supratentorial PNET, and recurrent brain tumors.

Last revised
Jun 22, 2026
Read time
≈ 1 min
Length
126 w
Citations
2
Source
Wikipedia ↗
Trofosfamide
Skeletal formula of trofosfamide
Ball-and-stick model of the trofosfamide molecule
Clinical data
Trade namesIxoten
AHFS/Drugs.comInternational Drug Names
Routes of
administration		By mouth (film-coated tablets)
ATC code
Legal status
Legal status
  • DE: § 48 AMG/§ 1 MPAV (Prescription only)
Identifiers
  • N,N,3-tris(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amide 2-oxide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.040.686
Chemical and physical data
FormulaC9H18Cl3N2O2P
Molar mass323.58 g·mol−1
3D model (JSmol)
  • C1CN(P(=O)(OC1)N(CCCl)CCCl)CCCl
  • InChI=1S/C9H18Cl3N2O2P/c10-2-6-13-5-1-9-16-17(13,15)14(7-3-11)8-4-12/h1-9H2 ☒N
  • Key:UMKFEPPTGMDVMI-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Trofosfamide (INN) is a nitrogen mustard alkylating agent. It is sometimes abbreviated "TRO".1 It has been used in trials to study its effects on ependymoma, medulloblastoma, sarcoma, soft tissue, supratentorial PNET, and recurrent brain tumors.2

References

References

  1. Jahnke K, Thiel E, Bechrakis NE, et al. (December 2008). "Ifosfamide or trofosfamide in patients with intraocular lymphoma". J. Neurooncol. 93 (2): 213–7. doi:10.1007/s11060-008-9761-8. PMID 19099202. S2CID 33892177.
  2. "Trofosfamide". www.drugbank.ca. Retrieved 2019-12-19.