Article · Wikipedia archive · Last revised Jul 26, 2026

Triethylenemelamine

Triethylenemelamine is a drug used in chemotherapy.

Last revised
Jul 26, 2026
Read time
≈ 1 min
Length
213 w
Citations
3
Source
Wikipedia ↗
Triethylenemelamine
Clinical data
ATC code
  • None
Identifiers
  • 2,4,6-Tris(aziridin-1-yl)-1,3,5-triazine
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.076
Chemical and physical data
FormulaC9H12N6
Molar mass204.237 g·mol−1
3D model (JSmol)
  • C1CN1c2nc(nc(n2)N3CC3)N4CC4
  • InChI=1S/C9H12N6/c1-2-13(1)7-10-8(14-3-4-14)12-9(11-7)15-5-6-15/h1-6H2 X markN
  • Key:IUCJMVBFZDHPDX-UHFFFAOYSA-N X markN
 X markNcheckY (what is this?)  (verify)

Triethylenemelamine (abbreviated TEM, also called Tretamine) is a drug used in chemotherapy.1

It is a mutagenic chemical because it is an alkylating antineoplastic agent, a trifunctional alkylating agent that has three reactive groups that enable it to bind covalently to DNA at three distinct sites. As a result, TEM can cause chromatid aberrations in cell models.2 It was one of the first compounds used for chemical mutagenesis in laboratory mice, with the impact on mutagenesis measured by the specific-locus test by Bruce Cattanach.3

See also

See also

References

References

  1. Wong JR, Morton LM, Tucker MA, Abramson DH, Seddon JM, Sampson JN, Kleinerman RA (October 2014). "Risk of subsequent malignant neoplasms in long-term hereditary retinoblastoma survivors after chemotherapy and radiotherapy". Journal of Clinical Oncology. 32 (29): 3284–3290. doi:10.1200/JCO.2013.54.7844. PMC 4178525. PMID 25185089.
  2. Luippold HE, Gooch PC, Brewen JG (February 1978). "The production of chromosome aberrations in various mammalian cells by triethylenemelamine". Genetics. 88 (2): 317–326. doi:10.1093/genetics/88.2.317. PMC 1213803. PMID 565312.
  3. Cattanach, B. M. (1966). "Chemically induced mutations in mice". Mutation Research. 3 (4): 346–353. doi:10.1016/0027-5107(66)90041-8. PMID 5969214.