Article · Wikipedia archive · Last revised Jun 22, 2026

Transdermal spray

A metered-dose transdermal spray delivers a drug to the skin surface for subsequent transdermal absorption. It functions similarly to other transdermal dosage forms such as patches and gels.

Last revised
Jun 22, 2026
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≈ 1 min
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Wikipedia ↗

A metered-dose transdermal spray delivers a drug to the skin surface for subsequent transdermal absorption. It functions similarly to other transdermal dosage forms such as patches and gels.1

In metered-dose transdermal sprays, a volatile solvent system rapidly dries after application, leaving the drug concentrated in or on the stratum corneum as a reservoir or depot from which it is released over time.2

An example of an approved transdermal spray is Evamist (estradiol transdermal spray), indicated for the treatment of moderate to severe vasomotor symptoms due to menopause.3

References

References

  1. Algın-Yapar, Esra; İnal, Özlem (2014). "Transdermal Spray in Hormone Delivery". Tropical Journal of Pharmaceutical Research. 13 (3). doi:10.4314/tjpr.v13i3.23.
  2. Mandal, U. K.; Jalalpure, S.; Gadade, D. (2016). "A Review on Transdermal Spray: Formulation Aspect" (PDF). Mathews Journal of Pharmaceutical Science. 1 (1). Retrieved 2026-04-17.
  3. "EVAMIST (estradiol transdermal spray) prescribing information" (PDF). U.S. Food and Drug Administration. Retrieved 2026-04-17.