Transcription initiation protein SPT3 homolog

SUPT3H
Identifiers
Aliases	SUPT3H, SPT3, SPT3L, SPT3 homolog, SAGA and STAGA complex component
External IDs	OMIM: 602947; MGI: 1923723; GeneCards: SUPT3H
Gene location (Human)
Chr.	Chromosome 6 (human)
End	45,377,953 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	45,430,177 bp
RNA expression pattern
	Top expressed in
	gonad; ; sperm; ; testicle; ; oocyte; ; left testis; ; sural nerve; ; right testis; ; cartilage tissue; ; ventricular zone; ; left ovary;
	Top expressed in
	hand; ; interventricular septum; ; muscle of thigh; ; primary oocyte; ; zygote; ; seminiferous tubule; ; spermatid; ; otolith organ; ; granulocyte; ; utricle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein heterodimerization activity; histone acetyltransferase activity; transcription coactivator activity; DNA binding; transcription coregulator activity;
Cellular component	transcription factor TFTC complex; nucleus; nucleoplasm; SAGA complex; transcription factor TFIID complex;
Biological process	regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; histone deubiquitination; regulation of transcription, DNA-templated; transcription by RNA polymerase II; histone H3 acetylation; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	8464
	109115
	ENSG00000196284
	ENSMUSG00000038954
	O75486
	n/a
NM_001261823; NM_003599; NM_181356; NM_001350324; NM_001350325;
	NM_001350326; NM_001350327; NM_001350329
	NM_178652; NM_001357320
NP_001248752; NP_003590; NP_852001; NP_001337253; NP_001337254;
	NP_001337255; NP_001337256; NP_001337258
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription initiation protein SPT3 homolog is a protein that in humans is encoded by the SUPT3H gene.⁵⁶⁷

Interactions

Transcription initiation protein SPT3 homolog has been shown to interact with GCN5L2,⁸⁹ TAF6L,⁹ TADA3L,⁹ TAF5L,⁹ SF3B3,⁹ SUPT7L,⁹ Myc,¹⁰ TAF9,⁹ Transformation/transcription domain-associated protein,⁹ TAF12,⁹ TAF10,⁸⁹ TAF4⁸ and DDB1.⁹

References

GRCh38: Ensembl release 89: ENSG00000196284 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038954 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y (Jul 1998). "Histone-like TAFs within the PCAF histone acetylase complex". Cell. 94 (1): 35–44. doi:10.1016/S0092-8674(00)81219-2. PMID 9674425. S2CID 18942972.
Martinez E, Kundu TK, Fu J, Roeder RG (Sep 1998). "A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID". The Journal of Biological Chemistry. 273 (37): 23781–5. doi:10.1074/jbc.273.37.23781. PMID 9726987.
"Entrez Gene: SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)".
Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L (Jun 2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". The EMBO Journal. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMC 150203. PMID 11406595.
Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (Oct 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Molecular and Cellular Biology. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863.
Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry. 278 (22): 20405–12. doi:10.1074/jbc.M211795200. PMC 4031917. PMID 12660246.

Further reading

Yu J, Madison JM, Mundlos S, Winston F, Olsen BR (Oct 1998). "Characterization of a human homologue of the Saccharomyces cerevisiae transcription factor spt3 (SUPT3H)". Genomics. 53 (1): 90–6. doi:10.1006/geno.1998.5500. PMID 9787080.
Vassilev A, Yamauchi J, Kotani T, Prives C, Avantaggiati ML, Qin J, Nakatani Y (Dec 1998). "The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily". Molecular Cell. 2 (6): 869–75. doi:10.1016/S1097-2765(00)80301-9. PMID 9885574.
Brand M, Yamamoto K, Staub A, Tora L (Jun 1999). "Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction". The Journal of Biological Chemistry. 274 (26): 18285–9. doi:10.1074/jbc.274.26.18285. PMID 10373431.
Speek M (Mar 2001). "Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes". Molecular and Cellular Biology. 21 (6): 1973–85. doi:10.1128/MCB.21.6.1973-1985.2001. PMC 86790. PMID 11238933.
Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L (Jun 2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". The EMBO Journal. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMC 150203. PMID 11406595.
Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (Oct 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Molecular and Cellular Biology. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863.
Cavusoglu N, Brand M, Tora L, Van Dorsselaer A (Feb 2003). "Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis". Proteomics. 3 (2): 217–23. doi:10.1002/pmic.200390030. PMID 12601814. S2CID 6035986.
Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry. 278 (22): 20405–12. doi:10.1074/jbc.M211795200. PMC 4031917. PMID 12660246.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196284 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038954 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9674425-5] Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y (Jul 1998). "Histone-like TAFs within the PCAF histone acetylase complex". Cell. 94 (1): 35–44. doi:10.1016/S0092-8674(00)81219-2. PMID 9674425. S2CID 18942972.

[pmid9726987-6] Martinez E, Kundu TK, Fu J, Roeder RG (Sep 1998). "A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID". The Journal of Biological Chemistry. 273 (37): 23781–5. doi:10.1074/jbc.273.37.23781. PMID 9726987.

[entrez-7] "Entrez Gene: SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)".

[pmid11406595-8] Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L (Jun 2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". The EMBO Journal. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMC 150203. PMID 11406595.

[pmid11564863-9] Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (Oct 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Molecular and Cellular Biology. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863.

[pmid12660246-10] Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry. 278 (22): 20405–12. doi:10.1074/jbc.M211795200. PMC 4031917. PMID 12660246.

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