TOR2A

TOR2A
Identifiers
Aliases	TOR2A, TORP1, torsin family 2 member A
External IDs	OMIM: 608052; MGI: 1353596; HomoloGene: 25260; GeneCards: TOR2A; OMA:TOR2A - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	127,735,313 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	32,762,244 bp
RNA expression pattern
	Top expressed in
	oocyte; ; granulocyte; ; monocyte; ; mucosa of transverse colon; ; gonad; ; secondary oocyte; ; left testis; ; right testis; ; blood; ; spleen;
	Top expressed in
	lacrimal gland; ; internal carotid artery; ; external carotid artery; ; parotid gland; ; seminal vesicula; ; lobe of prostate; ; vas deferens; ; submandibular gland; ; fossa; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATP binding; nucleotide binding; ATPase activity; hormone activity;
Cellular component	endoplasmic reticulum lumen; endoplasmic reticulum; nuclear envelope; extracellular region;
Biological process	protein homooligomerization; chaperone cofactor-dependent protein refolding; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of signaling receptor activity; positive regulation of gene expression; vasopressin secretion; water homeostasis; positive regulation of calcium ion transmembrane transport; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	27433
	30933
	ENSG00000160404
	ENSMUSG00000009563
	Q5JU69; Q8N2E6
	P0C7W3; Q8R1J9
NM_001085347; NM_001134430; NM_001134431; NM_001252018; NM_001252021;
	NM_001252023; NM_130459
	NM_152800
NP_001078816; NP_001127902; NP_001127903; NP_001238947; NP_001238950;
	NP_001238952; NP_569726; NP_001127902.1
	NP_690013; NP_001356151; NP_001356152; NP_001356153; NP_001356154
	Wikidata
View/Edit Human	View/Edit Mouse

Torsin-2A is a protein that in humans is encoded by the TOR2A gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000160404 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000009563 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ozelius LJ, Page CE, Klein C, Hewett JW, Mineta M, Leung J, Shalish C, Bressman SB, de Leon D, Brin MF, Fahn S, Corey DP, Breakefield XO (Mar 2000). "The TOR1A (DYT1) gene family and its role in early onset torsion dystonia". Genomics. 62 (3): 377–84. doi:10.1006/geno.1999.6039. PMID 10644435.
"Entrez Gene: TOR2A torsin family 2, member A".

Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shichiri M, Ishimaru S, Ota T, et al. (2003). "Salusins: newly identified bioactive peptides with hemodynamic and mitogenic activities". Nat. Med. 9 (9): 1166–72. doi:10.1038/nm913. PMID 12910263. S2CID 52806064.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Wang Z, Takahashi T, Saito Y, et al. (2006). "Salusin beta is a surrogate ligand of the mas-like G protein-coupled receptor MrgA1". Eur. J. Pharmacol. 539 (3): 145–50. doi:10.1016/j.ejphar.2006.03.064. PMID 16697365.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160404 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000009563 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10644435-5] Ozelius LJ, Page CE, Klein C, Hewett JW, Mineta M, Leung J, Shalish C, Bressman SB, de Leon D, Brin MF, Fahn S, Corey DP, Breakefield XO (Mar 2000). "The TOR1A (DYT1) gene family and its role in early onset torsion dystonia". Genomics. 62 (3): 377–84. doi:10.1006/geno.1999.6039. PMID 10644435.

[entrez-6] "Entrez Gene: TOR2A torsin family 2, member A".

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