Article · Wikipedia archive · Last revised Jul 29, 2026

Tocofersolan

Tocofersolan is a synthetic water-soluble version of vitamin E. Natural forms of vitamin E are fat soluble, but not water-soluble. Tocofersolan is a polyethylene glycol (PEG) derivative of α-tocopherol succinate. The addition of PEG enables water solubility.

Last revised
Jul 29, 2026
Read time
≈ 1 min
Length
334 w
Citations
5
Source
Wikipedia ↗

Tocofersolan
source ↗
Names
IUPAC name
α-Hydro-ω-{[4-oxo-4-({(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl}oxy)butanoyl]oxy}poly(oxyethylene)
Other names
Tocofersolan; Vitamin E PEG succinate; α-Tocopherol polyethylene glycol succinate (TPGS); Liqui-E
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.123.651
EC Number
  • 618-345-6
UNII
  • InChI=1S/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3 checkY
    Key: AOBORMOPSGHCAX-UHFFFAOYSA-N checkY
  • InChI=1/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3
    Key: AOBORMOPSGHCAX-UHFFFAOYAU
  • O=C(OCCO)CCC(=O)Oc2c(c(c1OC(CCc1c2C)(C)CCCC(C)CCCC(C)CCCC(C)C)C)C
Properties
(C2H4O)nC33H54O5
Molar mass Variable
Pharmacology
A11HA08 (WHO)
License data
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Tocofersolan
Clinical data
Trade namesVedrop
Other namesTocophersolan (USAN US)
AHFS/Drugs.comUK Drug Information
Legal status
Legal status
  • UK: POM (Prescription only)1
  • EU: Rx-only2
Identifiers
DrugBank
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.123.651

Tocofersolan (INN; also known as tocophersolan, tocopherol polyethylene glycol succinate, or TPGS) is a synthetic water-soluble version of vitamin E. Natural forms of vitamin E are fat soluble, but not water-soluble. Tocofersolan is a polyethylene glycol (PEG) derivative of α-tocopherol succinate. The addition of PEG enables water solubility.

Tocofersolan is used as a vitamin E supplement or to treat vitamin E deficiency in individuals who cannot absorb fats due to disease.3 On 24 July 2009 the European Medicines Agency approved tocofersolan under the trade name Vedrop 50 mg/ml oral solution for the treatment of vitamin E deficiency due to digestive malabsorption in paediatric patients with congenital or hereditary chronic cholestasis, from birth (in term newborns) to 16 or 18 years of age (depending on the region).4

Tocofersolan is also used in cosmetics and pharmaceuticals as an antioxidant.5

References

References

  1. "Vedrop 50 mg/ml oral solution - Summary of Product Characteristics (SmPC)". (emc). 19 June 2019. Retrieved 24 July 2020.
  2. "Vedrop EPAR". European Medicines Agency (EMA). Archived from the original on 24 July 2020. Retrieved 24 July 2020.
  3. "Tocophersolan Oral". WebMD.
  4. "Vedrop Summary of Product Characteristics" (PDF). European Medicines Agency.
  5. Ash M, Ash I (2004). Handbook of Preservatives. Synapse Info Resources. p. 568. ISBN 1-890595-66-7.