TNS1

TNS1
Identifiers
Aliases	TNS1, MST091, MST122, MST127, MSTP122, MSTP127, MXRA6, PPP1R155, TNS, MSTP091, tensin 1
External IDs	OMIM: 600076; MGI: 104552; HomoloGene: 11219; GeneCards: TNS1; OMA:TNS1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	218,002,995 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	74,163,608 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; urethra; ; tail of epididymis; ; lower lobe of lung; ; seminal vesicula; ; myocardium of left ventricle; ; cardiac muscle tissue of right atrium; ; right coronary artery; ; popliteal artery; ; tibial arteries;
	Top expressed in
	ascending aorta; ; aortic valve; ; interventricular septum; ; right lung; ; left lung; ; right lung lobe; ; left lung lobe; ; muscle of thigh; ; tunica media of zone of aorta; ; myocardium of ventricle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	actin binding; protein binding; RNA binding;
Cellular component	cytoplasm; cell-substrate junction; cell surface; cell junction; cytoskeleton; focal adhesion;
Biological process	cell-substrate junction assembly; fibroblast migration;
	Sources:Amigo / QuickGO
Orthologs
	7145
	21961
	ENSG00000079308
	ENSMUSG00000055322
	Q9HBL0; Q0VG54
	n/a
	NM_001308022; NM_001308023; NM_022648
	NM_001289895; NM_027884; NM_177169
	NP_001294951; NP_001294952; NP_072174; NP_001294951.1; NP_001294952.1
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Tensin-1 is a protein that in humans is encoded by the TNS1 gene.⁵

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature has not been determined.⁵

References

GRCh38: Ensembl release 89: ENSG00000079308 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000055322 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: TNS1 tensin 1".

External links

TNS1 Archived 2011-07-22 at the Wayback Machine Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine

Further reading

Jankowski SA, Gumucio DL (1996). "Genes for tensin, villin and desmin are linked on mouse chromosome 1" (PDF). Mamm. Genome. 6 (10): 744–5. doi:10.1007/BF00354299. hdl:2027.42/47016. PMID 8563175. S2CID 22316923.
Salgia R, Pisick E, Sattler M, et al. (1996). "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". J. Biol. Chem. 271 (41): 25198–203. doi:10.1074/jbc.271.41.25198. PMID 8810278.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Katz BZ, Zohar M, Teramoto H, et al. (2000). "Tensin can induce JNK and p38 activation". Biochem. Biophys. Res. Commun. 272 (3): 717–20. doi:10.1006/bbrc.2000.2853. PMID 10860821.
Chen H, Ishii A, Wong WK, et al. (2001). "Molecular characterization of human tensin". Biochem. J. 351 Pt 2 (2): 403–11. doi:10.1042/0264-6021:3510403. PMC 1221376. PMID 11023826.
Benzing T, Gerke P, Höpker K, et al. (2001). "Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9784–9. Bibcode:2001PNAS...98.9784B. doi:10.1073/pnas.171269898. PMC 55530. PMID 11493697.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Yamashita M, Horikoshi S, Asanuma K, et al. (2004). "Tensin is potentially involved in extracellular matrix production in mesangial cells". Histochem. Cell Biol. 121 (3): 245–54. doi:10.1007/s00418-004-0626-8. PMID 14991332. S2CID 5634607.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Eto M, Kirkbride J, Elliott E, et al. (2007). "Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase-1 in focal adhesions". J. Biol. Chem. 282 (24): 17806–15. doi:10.1074/jbc.M700944200. PMID 17435217.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000079308 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055322 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TNS1 tensin 1".

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