TMF1

TMF1
Identifiers
Aliases	TMF1, ARA160, TMF, TATA element modulatory factor 1
External IDs	OMIM: 601126; MGI: 2684999; HomoloGene: 133801; GeneCards: TMF1; OMA:TMF1 - orthologs
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	97,156,083 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; stromal cell of endometrium; ; caput epididymis; ; islet of Langerhans; ; bronchial epithelial cell; ; right uterine tube; ; corpus epididymis; ; rectum; ; body of pancreas; ; minor salivary glands;
	Top expressed in
	spermatid; ; otolith organ; ; spermatocyte; ; utricle; ; zygote; ; iris; ; tail of embryo; ; genital tubercle; ; secondary oocyte; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription coregulator activity; protein binding;
Cellular component	cytoplasm; Golgi apparatus; membrane; Golgi membrane; endoplasmic reticulum; nucleus; cytosol;
Biological process	flagellated sperm motility; regulation of proteasomal protein catabolic process; male gonad development; regulation of transcription, DNA-templated; Leydig cell differentiation; positive regulation of cytokine production; cellular response to organic cyclic compound; negative regulation of apoptotic process; transcription by RNA polymerase II; negative regulation of gene expression; transcription, DNA-templated; positive regulation of testosterone secretion; defense response to bacterium; acrosome assembly; spermatid development; luteinizing hormone secretion; spermatid nucleus differentiation;
	Sources:Amigo / QuickGO
Orthologs
	7110
	232286
	n/a
	ENSMUSG00000030059
	P82094; Q6PII6
	B9EKI3
	NM_007114; NM_001363879
	NM_001081111
	NP_009045; NP_001350808; NP_009045.2
	NP_001074580
	Wikidata
View/Edit Human	View/Edit Mouse

TATA element modulatory factor is a protein that in humans is encoded by the TMF1 gene.⁴⁵

Interactions

TMF1 has been shown to interact with FER⁶ and Androgen receptor.⁷

References

GRCm38: Ensembl release 89: ENSMUSG00000030059 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Garcia JA, Ou SH, Wu F, Lusis AJ, Sparkes RS, Gaynor RB (Nov 1992). "Cloning and chromosomal mapping of a human immunodeficiency virus 1 "TATA" element modulatory factor". Proc Natl Acad Sci U S A. 89 (20): 9372–6. Bibcode:1992PNAS...89.9372G. doi:10.1073/pnas.89.20.9372. PMC 50133. PMID 1409643.
"Entrez Gene: TMF1 TATA element modulatory factor 1".
Schwartz, Y; Ben-Dor I; Navon A; Motro B; Nir U (Sep 1998). "Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases". FEBS Lett. 434 (3): 339–45. Bibcode:1998FEBSL.434..339S. doi:10.1016/S0014-5793(98)01003-5. ISSN 0014-5793. PMID 9742951. S2CID 24338520.
Hsiao, P W; Chang C (Aug 1999). "Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells". J. Biol. Chem. 274 (32): 22373–9. doi:10.1074/jbc.274.32.22373. ISSN 0021-9258. PMID 10428808.

Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Schwartz Y, Ben-Dor I, Navon A, et al. (1998). "Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases". FEBS Lett. 434 (3): 339–45. Bibcode:1998FEBSL.434..339S. doi:10.1016/S0014-5793(98)01003-5. PMID 9742951. S2CID 24338520.
Hsiao PW, Chang C (1999). "Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells". J. Biol. Chem. 274 (32): 22373–9. doi:10.1074/jbc.274.32.22373. PMID 10428808.
Mori K, Kato H (2002). "A putative nuclear receptor coactivator (TMF/ARA160) associates with hbrm/hSNF2 alpha and BRG-1/hSNF2 beta and localizes in the Golgi apparatus". FEBS Lett. 520 (1–3): 127–32. Bibcode:2002FEBSL.520..127M. doi:10.1016/S0014-5793(02)02803-X. PMID 12044884. S2CID 84784473.
Zhang Y, Fondell JD, Wang Q, et al. (2002). "Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1". Oncogene. 21 (36): 5609–18. doi:10.1038/sj.onc.1205638. PMID 12165860. S2CID 22209143.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Fridmann-Sirkis Y, Siniossoglou S, Pelham HR (2004). "TMF is a golgin that binds Rab6 and influences Golgi morphology". BMC Cell Biol. 5: 18. doi:10.1186/1471-2121-5-18. PMC 419336. PMID 15128430.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Yamane J, Kubo A, Nakayama K, et al. (2007). "Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic" (PDF). Exp. Cell Res. 313 (16): 3472–85. doi:10.1016/j.yexcr.2007.07.010. hdl:2433/135781. PMID 17698061.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000030059 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1409643-4] Garcia JA, Ou SH, Wu F, Lusis AJ, Sparkes RS, Gaynor RB (Nov 1992). "Cloning and chromosomal mapping of a human immunodeficiency virus 1 "TATA" element modulatory factor". Proc Natl Acad Sci U S A. 89 (20): 9372–6. Bibcode:1992PNAS...89.9372G. doi:10.1073/pnas.89.20.9372. PMC 50133. PMID 1409643.

[entrez-5] "Entrez Gene: TMF1 TATA element modulatory factor 1".

[pmid9742951-6] Schwartz, Y; Ben-Dor I; Navon A; Motro B; Nir U (Sep 1998). "Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases". FEBS Lett. 434 (3): 339–45. Bibcode:1998FEBSL.434..339S. doi:10.1016/S0014-5793(98)01003-5. ISSN 0014-5793. PMID 9742951. S2CID 24338520.

[pmid10428808-7] Hsiao, P W; Chang C (Aug 1999). "Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells". J. Biol. Chem. 274 (32): 22373–9. doi:10.1074/jbc.274.32.22373. ISSN 0021-9258. PMID 10428808.

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