TMED2

TMED2
Identifiers
Aliases	TMED2, P24A, RNP24, p24, p24b1, p24beta1, transmembrane p24 trafficking protein 2
External IDs	MGI: 3704329; HomoloGene: 55991; GeneCards: TMED2; OMA:TMED2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	123,598,582 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; corpus epididymis; ; pylorus; ; pericardium; ; trachea; ; caput epididymis; ; cardia; ; human penis; ; superior surface of tongue; ; Epithelium of choroid plexus;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	transport vesicle; integral component of membrane; ER to Golgi transport vesicle membrane; Golgi apparatus; Golgi membrane; intracellular membrane-bounded organelle; Golgi cisterna membrane; zymogen granule membrane; membrane; endoplasmic reticulum; endoplasmic reticulum membrane; cytoplasmic vesicle membrane; cytoplasmic vesicle; COPI-coated vesicle; endoplasmic reticulum-Golgi intermediate compartment membrane; endoplasmic reticulum-Golgi intermediate compartment; COPI-coated vesicle membrane; COPII-coated ER to Golgi transport vesicle;
Biological process	vesicle cargo loading; neural tube closure; maternal placenta development; embryonic placenta development; COPII vesicle coating; endoplasmic reticulum to Golgi vesicle-mediated transport; heart looping; positive regulation of gene expression; somitogenesis; Golgi organization; post-anal tail morphogenesis; embryonic morphogenesis; multicellular organism growth; in utero embryonic development; protein transport; negative regulation of GTPase activity; COPI coating of Golgi vesicle; labyrinthine layer blood vessel development; vesicle-mediated transport; somite rostral/caudal axis specification; intracellular protein transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	10959
	100862175
	ENSG00000086598
	n/a
	Q15363
	Q9R0Q3
	NM_006815; NM_001321445
	XM_003945446
	NP_001308374; NP_006806
	NP_062744; NP_001390182; NP_001390186
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane emp24 domain-containing protein 2 is a protein that in humans is encoded by the TMED2 gene.⁴⁵

Interactions

TMED2 has been shown to interact with GORASP1⁶ and GORASP2.⁶

References

GRCh38: Ensembl release 89: ENSG00000086598 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Blum R, Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, Schulz I (July 1996). "Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking". The Journal of Biological Chemistry. 271 (29): 17183–9. doi:10.1074/jbc.271.29.17183. PMID 8663407.
"Entrez Gene: TMED2 transmembrane emp24 domain trafficking protein 2".
Barr FA, Preisinger C, Kopajtich R, Körner R (December 2001). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". The Journal of Cell Biology. 155 (6): 885–91. doi:10.1083/jcb.200108102. PMC 2150891. PMID 11739402.

Further reading

Fiedler K, Veit M, Stamnes MA, Rothman JE (September 1996). "Bimodal interaction of coatomer with the p24 family of putative cargo receptors". Science. 273 (5280): 1396–9. Bibcode:1996Sci...273.1396F. doi:10.1126/science.273.5280.1396. PMID 8703076. S2CID 13159384.
Gommel D, Orci L, Emig EM, Hannah MJ, Ravazzola M, Nickel W, Helms JB, Wieland FT, Sohn K (March 1999). "p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway". FEBS Letters. 447 (2–3): 179–85. doi:10.1016/S0014-5793(99)00246-X. PMID 10214941. S2CID 41832392.
Majoul I, Straub M, Hell SW, Duden R, Söling HD (July 2001). "KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET". Developmental Cell. 1 (1): 139–53. doi:10.1016/S1534-5807(01)00004-1. PMID 11703931.
Barr FA, Preisinger C, Kopajtich R, Körner R (December 2001). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". The Journal of Cell Biology. 155 (6): 885–91. doi:10.1083/jcb.200108102. PMC 2150891. PMID 11739402.
Breuza L, Halbeisen R, Jenö P, Otte S, Barlowe C, Hong W, Hauri HP (November 2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". The Journal of Biological Chemistry. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, Marambaud P, Hansen K, Westaway D, St George-Hyslop P, Fraser P (April 2006). "TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity". Nature. 440 (7088): 1208–12. Bibcode:2006Natur.440.1208C. doi:10.1038/nature04667. PMID 16641999. S2CID 4349251.
Luo W, Wang Y, Reiser G (October 2007). "p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking". The Journal of Biological Chemistry. 282 (41): 30246–55. doi:10.1074/jbc.M703205200. PMID 17693410.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000086598 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8663407-4] Blum R, Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, Schulz I (July 1996). "Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking". The Journal of Biological Chemistry. 271 (29): 17183–9. doi:10.1074/jbc.271.29.17183. PMID 8663407.

[entrez-5] "Entrez Gene: TMED2 transmembrane emp24 domain trafficking protein 2".

[pmid11739402-6] Barr FA, Preisinger C, Kopajtich R, Körner R (December 2001). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". The Journal of Cell Biology. 155 (6): 885–91. doi:10.1083/jcb.200108102. PMC 2150891. PMID 11739402.

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