TLE3

TLE3
Identifiers
Aliases	TLE3, ESG, ESG3, GRG3, HsT18976, transducin like enhancer of split 3, TLE family member 3, transcriptional corepressor
External IDs	OMIM: 600190; MGI: 104634; HomoloGene: 21059; GeneCards: TLE3; OMA:TLE3 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	70,098,176 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	61,325,779 bp
RNA expression pattern
	Top expressed in
	blood; ; ganglionic eminence; ; sural nerve; ; ventricular zone; ; skin of leg; ; buccal mucosa cell; ; right testis; ; monocyte; ; left testis; ; skin of abdomen;
	Top expressed in
	genital tubercle; ; Rostral migratory stream; ; tail of embryo; ; granulocyte; ; decidua; ; ventricular zone; ; hair follicle; ; lacrimal gland; ; intestinal villus; ; molar;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; transcription corepressor activity;
Cellular component	nucleus; nucleoplasm; beta-catenin-TCF complex; transcription regulator complex;
Biological process	animal organ morphogenesis; regulation of transcription, DNA-templated; Wnt signaling pathway; transcription, DNA-templated; signal transduction; beta-catenin-TCF complex assembly; negative regulation of canonical Wnt signaling pathway; negative regulation of cold-induced thermogenesis; negative regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	7090
	21887
	ENSG00000140332
	ENSMUSG00000032280
	Q04726; Q6PRX3
	Q08122
NM_001105192; NM_001282979; NM_001282980; NM_001282981; NM_001282982;
	NM_005078; NM_020908
	NM_001083927; NM_001083928; NM_009389
NP_001098662; NP_001269908; NP_001269909; NP_001269910; NP_001269911;
	NP_005069; NP_065959; NP_001269908.1
	NP_001077396; NP_001077397; NP_033415
	Wikidata
View/Edit Human	View/Edit Mouse

Transducin-like enhancer protein 3 is a protein that in humans is encoded by the TLE3 gene.⁵⁶

TLE3 expression has been linked to higher survival rates for lung cancer patients.⁷

References

GRCh38: Ensembl release 89: ENSG00000140332 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000032280 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Miyasaka H, Choudhury BK, Hou EW, Li SS (Aug 1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein". European Journal of Biochemistry. 216 (1): 343–52. doi:10.1111/j.1432-1033.1993.tb18151.x. PMID 8365415.
"Entrez Gene: TLE3 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)".
"Research update from the MCM team (February 2024)". World Community Grid. 16 February 2024. Retrieved 21 May 2024.

Further reading

Stifani S, Blaumueller CM, Redhead NJ, Hill RE, Artavanis-Tsakonas S (Oct 1992). "Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins". Nature Genetics. 2 (2): 119–27. doi:10.1038/ng1092-119. PMID 1303260. S2CID 32142845.
Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S (Jan 1996). "Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia". Genomics. 31 (1): 58–64. doi:10.1006/geno.1996.0009. PMID 8808280.
Wang JC, Waltner-Law M, Yamada K, Osawa H, Stifani S, Granner DK (Jun 2000). "Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta". The Journal of Biological Chemistry. 275 (24): 18418–23. doi:10.1074/jbc.M910211199. PMID 10748198.
Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Aug 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
Yao J, Lai E, Stifani S (Mar 2001). "The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription". Molecular and Cellular Biology. 21 (6): 1962–72. doi:10.1128/MCB.21.6.1962-1972.2001. PMC 86788. PMID 11238932.
Nuthall HN, Joachim K, Palaparti A, Stifani S (Dec 2002). "A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression". The Journal of Biological Chemistry. 277 (52): 51049–57. doi:10.1074/jbc.M111660200. PMID 12397081.
López-Ríos J, Tessmar K, Loosli F, Wittbrodt J, Bovolenta P (Jan 2003). "Six3 and Six6 activity is modulated by members of the groucho family". Development. 130 (1): 185–95. doi:10.1242/dev.00185. PMID 12441302.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Tu LC, Yan X, Hood L, Lin B (Apr 2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells". Molecular & Cellular Proteomics. 6 (4): 575–88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1) 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140332 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032280 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8365415-5] Miyasaka H, Choudhury BK, Hou EW, Li SS (Aug 1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein". European Journal of Biochemistry. 216 (1): 343–52. doi:10.1111/j.1432-1033.1993.tb18151.x. PMID 8365415.

[entrez-6] "Entrez Gene: TLE3 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)".

[7] "Research update from the MCM team (February 2024)". World Community Grid. 16 February 2024. Retrieved 21 May 2024.

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