TJP3

TJP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3KFV
Identifiers
Aliases	TJP3, ZO-3, ZO3, tight junction protein 3
External IDs	OMIM: 612689; MGI: 1351650; HomoloGene: 8458; GeneCards: TJP3; OMA:TJP3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	3,750,813 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	81,127,415 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; right uterine tube; ; olfactory zone of nasal mucosa; ; left testis; ; right testis; ; nasal epithelium; ; buccal mucosa cell; ; epithelium of bronchus; ; bronchial epithelial cell; ; rectum;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; left colon; ; ileum; ; epithelium of stomach; ; jejunum; ; intestinal villus; ; duodenum; ; mucous cell of stomach; ; transitional epithelium of urinary bladder; ; pyloric antrum;
	More reference expression data
	More reference expression data
Orthologs
	27134
	27375
	ENSG00000105289
	ENSMUSG00000034917
	O95049
	Q9QXY1
	NM_014428; NM_001267560; NM_001267561
	NM_001282095; NM_001282096; NM_013769
	NP_001254489; NP_001254490
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Tight junction protein ZO-3 is a protein that in humans is encoded by the TJP3 gene.⁵

Interactions

References

Further reading

Roh MH, Liu CJ, Laurinec S, Margolis B (July 2002). "The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions". The Journal of Biological Chemistry. 277 (30): 27501–9. doi:10.1074/jbc.M201177200. PMID 12021270.
Kausalya PJ, Reichert M, Hunziker W (September 2001). "Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells". FEBS Letters. 505 (1): 92–6. Bibcode:2001FEBSL.505...92K. doi:10.1016/S0014-5793(01)02786-7. PMID 11557048. S2CID 13489358.
Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S (December 1999). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins". The Journal of Cell Biology. 147 (6): 1351–63. doi:10.1083/jcb.147.6.1351. PMC 2168087. PMID 10601346.
Wittchen ES, Haskins J, Stevenson BR (December 1999). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3". The Journal of Biological Chemistry. 274 (49): 35179–85. doi:10.1074/jbc.274.49.35179. PMID 10575001.
Haskins J, Gu L, Wittchen ES, Hibbard J, Stevenson BR (April 1998). "ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin". The Journal of Cell Biology. 141 (1): 199–208. doi:10.1083/jcb.141.1.199. PMC 2132714. PMID 9531559.