TIMM10B

TIMM10B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BSK
Identifiers
Aliases	TIMM10B, FXC1, TIM10B, Tim9b, translocase of inner mitochondrial membrane 10 homolog B (yeast), translocase of inner mitochondrial membrane 10B
External IDs	OMIM: 607388; MGI: 1315196; HomoloGene: 8142; GeneCards: TIMM10B; OMA:TIMM10B - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	6,484,681 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	105,643,637 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; tibia; ; sperm; ; gonad; ; saphenous vein; ; epithelium of colon; ; superior vestibular nucleus; ; spinal ganglia; ; ventral tegmental area; ; amniotic fluid;
	Top expressed in
	granulocyte; ; right kidney; ; embryo; ; embryo; ; muscle of thigh; ; lip; ; ventricular zone; ; superior frontal gyrus; ; yolk sac; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein binding;
Cellular component	mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial intermembrane space protein transporter complex; mitochondrion; membrane; TIM22 mitochondrial import inner membrane insertion complex;
Biological process	protein transport; protein targeting to mitochondrion; cell-matrix adhesion;
	Sources:Amigo / QuickGO
Orthologs
	26515
	14356
	ENSG00000132286
	ENSMUSG00000089847
	Q9Y5J6
	Q9WV96
	NM_012192
	NM_019502
	NP_036324
NP_062375; NP_001346981; NP_001346982; NP_001346983; NP_001346984;
	NP_001346985; NP_001346987; NP_001346988; NP_001346989; NP_001346990
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial import inner membrane translocase subunit Tim9 B is an enzyme that in humans is encoded by the FXC1 gene.⁵⁶

FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM]⁶

References

GRCh38: Ensembl release 89: ENSG00000132286 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000089847 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Jin H, Kendall E, Freeman TC, Roberts RG, Vetrie DL (Feb 2000). "The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins". Genomics. 61 (3): 259–67. doi:10.1006/geno.1999.5966. PMID 10552927.
"Entrez Gene: FXC1 fracture callus 1 homolog (rat)".

Further reading

Hadjiargyrou M, Halsey MF, Ahrens W, et al. (1998). "Cloning of a novel cDNA expressed during the early stages of fracture healing". Biochem. Biophys. Res. Commun. 249 (3): 879–84. doi:10.1006/bbrc.1998.9167. PMID 9731230.
Bauer MF, Rothbauer U, Mühlenbein N, et al. (2000). "The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom". FEBS Lett. 464 (1–2): 41–7. doi:10.1016/S0014-5793(99)01665-8. PMID 10611480. S2CID 27484018.
Rothbauer U, Hofmann S, Mühlenbein N, et al. (2001). "Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria". J. Biol. Chem. 276 (40): 37327–34. doi:10.1074/jbc.M105313200. PMID 11489896.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Mühlenbein N, Hofmann S, Rothbauer U, Bauer MF (2004). "Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria". J. Biol. Chem. 279 (14): 13540–6. doi:10.1074/jbc.M312485200. PMID 14726512.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132286 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000089847 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10552927-5] Jin H, Kendall E, Freeman TC, Roberts RG, Vetrie DL (Feb 2000). "The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins". Genomics. 61 (3): 259–67. doi:10.1006/geno.1999.5966. PMID 10552927.

[entrez-6] "Entrez Gene: FXC1 fracture callus 1 homolog (rat)".

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