Teaghrelins

Chemical structure of teaghrelin-1 source ↗

Teaghrelins are acylated flavonoid tetraglycosides found in semi-oxidized oolong teas (Camellia sinensis), such as Chin-shin oolong tea¹ and Shy‐jih‐chuen oolong tea.²

Teaghrelins are ghrelin receptor agonists in vitro.¹ In an animal model, teaghrelins induce hunger and accelerate gastric emptying.¹ Teaghrelins also has growth hormone releasing activity on the anterior pituitary gland, similar to the synthetic ghrelin analog GHRP-6, that could be inhibited by a ghrelin receptor antagonist.¹

References

Lo, Yuan-Hao; Chen, Ying-Jie; Chang, Chi-I; Lin, Yi-Wen; Chen, Chung-Yu; Lee, Maw-Rong; Lee, Viola S. Y.; Tzen, Jason T. C. (2014). "Teaghrelins, Unique Acylated Flavonoid Tetraglycosides in Chin-Shin Oolong Tea, Are Putative Oral Agonists of the Ghrelin Receptor". Journal of Agricultural and Food Chemistry. 62 (22): 5085–5091. doi:10.1021/jf501425m. PMID 24832927.
Li, Yue‐Chiun; Wu, Chieh‐Ju; Lin, Yi‐Chiao; Wu, Ruo‐Hsuan; Chen, Wen‐Ying; Kuo, Ping‐Chung; Tzen, Jason T. C. (2019). "Identification of two teaghrelins in Shy‐jih‐chuen oolong tea". Journal of Food Biochemistry. 43 (4) e12810. doi:10.1111/jfbc.12810. PMID 31353599.

[lo-1] Lo, Yuan-Hao; Chen, Ying-Jie; Chang, Chi-I; Lin, Yi-Wen; Chen, Chung-Yu; Lee, Maw-Rong; Lee, Viola S. Y.; Tzen, Jason T. C. (2014). "Teaghrelins, Unique Acylated Flavonoid Tetraglycosides in Chin-Shin Oolong Tea, Are Putative Oral Agonists of the Ghrelin Receptor". Journal of Agricultural and Food Chemistry. 62 (22): 5085–5091. doi:10.1021/jf501425m. PMID 24832927.

[2] Li, Yue‐Chiun; Wu, Chieh‐Ju; Lin, Yi‐Chiao; Wu, Ruo‐Hsuan; Chen, Wen‐Ying; Kuo, Ping‐Chung; Tzen, Jason T. C. (2019). "Identification of two teaghrelins in Shy‐jih‐chuen oolong tea". Journal of Food Biochemistry. 43 (4) e12810. doi:10.1111/jfbc.12810. PMID 31353599.

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