TAF13

TAF13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BH8, 1BH9
Identifiers
Aliases	TAF13, TAF(II)18, TAF2K, TAFII-18, TAFII18, TATA-box binding protein associated factor 13, MRT60
External IDs	OMIM: 600774; MGI: 1913500; HomoloGene: 4126; GeneCards: TAF13; OMA:TAF13 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)1 Band 1p13.3 Start 109,062,496 bp1 End 109,076,012 bp1
Gene location (Mouse) Chr. Chromosome 3 (mouse)2 Band 3|3 F3 Start 108,479,014 bp2 End 108,490,538 bp2
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus lateral nuclear group of thalamus gingival epithelium Brodmann area 23 amniotic fluid pars reticulata endothelial cell pons subthalamic nucleus pars compacta Top expressed in zygote secondary oocyte primary oocyte zone of skin layer of retina neural layer of retina quadriceps femoris muscle morula ventricular zone spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity protein C-terminus binding protein binding protein heterodimerization activity DNA binding transcription coregulator activity Cellular component nucleolus transcription factor TFIID complex nucleus nucleoplasm Biological process transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated DNA-templated transcription, initiation snRNA transcription by RNA polymerase II regulation of signal transduction by p53 class mediator regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6884 99730 Ensembl ENSG00000197780 ENSMUSG00000048100 UniProt Q15543 P61216 RefSeq (mRNA) NM_005645 NM_025444 RefSeq (protein) NP_005636 NP_079720 Location (UCSC) Chr 1: 109.06 – 109.08 Mb Chr 3: 108.48 – 108.49 Mb PubMed search 3 4
Wikidata
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Transcription initiation factor TFIID subunit 13 is a protein that in humans is encoded by the TAF13 gene.⁵⁶

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6.⁶

TAF13 has been shown to interact with TAF15,⁷ TAF11,⁵⁸ TAF10⁵ and TATA binding protein.⁵