SYT6

SYT6
Identifiers
Aliases	SYT6, sytVI, synaptotagmin 6
External IDs	OMIM: 607718; MGI: 1859544; HomoloGene: 10301; GeneCards: SYT6; OMA:SYT6 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	114,153,880 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	103,552,885 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; ganglionic eminence; ; nucleus accumbens; ; hypothalamus; ; tibialis anterior muscle; ; caudate nucleus; ; primary visual cortex; ; putamen; ; mucosa of ileum; ; prefrontal cortex;
	Top expressed in
	multiform layer of neocortex; ; superior frontal gyrus; ; olfactory bulb; ; pretectal area; ; Rostral migratory stream; ; primary visual cortex; ; lumbar spinal ganglion; ; olfactory tubercle; ; dentate gyrus of hippocampal formation granule cell; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; protein homodimerization activity; clathrin binding; calcium-dependent protein binding; metal ion binding; protein binding; identical protein binding; calcium-dependent phospholipid binding; syntaxin binding; phosphatidylserine binding; SNARE binding;
Cellular component	cytoplasm; integral component of membrane; cytosol; membrane; perinuclear endoplasmic reticulum; synapse; synaptic vesicle membrane; cell junction; cytoplasmic vesicle; plasma membrane; extrinsic component of membrane; glutamatergic synapse; integral component of synaptic membrane; exocytic vesicle;
Biological process	acrosomal vesicle exocytosis; acrosome reaction; regulation of calcium ion-dependent exocytosis; calcium ion-regulated exocytosis of neurotransmitter; vesicle fusion; presynaptic dense core vesicle exocytosis; regulation of dopamine secretion; synaptic vesicle exocytosis; vesicle-mediated transport; calcium-ion regulated exocytosis; cellular response to calcium ion;
	Sources:Amigo / QuickGO
Orthologs
	148281
	54524
	ENSG00000134207
	ENSMUSG00000027849
	Q5T7P8
	Q9R0N8
NM_001253772; NM_001270805; NM_205848; NM_001366223; NM_001366224;
	NM_001366225; NM_001366226
NM_001276676; NM_001276677; NM_001276679; NM_001276680; NM_001276681;
	NM_018800
NP_001257734; NP_995320; NP_001240701; NP_001353152; NP_001353153;
	NP_001353154; NP_001353155
NP_001263605; NP_001263606; NP_001263608; NP_001263609; NP_001263610;
	NP_061270
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptotagmin-6 is a protein that in humans is encoded by the SYT6 gene.⁵⁶

Function

Synaptotagmins, such as SYT6, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis. For further information on synaptotagmins, see MIM 185605.[supplied by OMIM]⁶

References

GRCh38: Ensembl release 89: ENSG00000134207 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027849 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Craxton M (September 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
"Entrez Gene: SYT6 synaptotagmin VI".

Further reading

Roggero CM, Tomes CN, De Blas GA, Castillo J, Michaut MA, Fukuda M, Mayorga LS (September 2005). "Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis". Developmental Biology. 285 (2): 422–35. doi:10.1016/j.ydbio.2005.07.007. PMID 16111671.
Michaut M, De Blas G, Tomes CN, Yunes R, Fukuda M, Mayorga LS (July 2001). "Synaptotagmin VI participates in the acrosome reaction of human spermatozoa". Developmental Biology. 235 (2): 521–9. doi:10.1006/dbio.2001.0316. PMID 11437455.
Perin MS (October 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC (June 1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature. 375 (6532): 594–9. Bibcode:1995Natur.375..594L. doi:10.1038/375594a0. PMID 7791877. S2CID 4265549.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134207 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027849 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11543631-5] Craxton M (September 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.

[entrez-6] "Entrez Gene: SYT6 synaptotagmin VI".

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