SV2B

SV2B
Identifiers
Aliases	SV2B, HsT19680, synaptic vesicle glycoprotein 2B
External IDs	OMIM: 185861; MGI: 1927338; HomoloGene: 32236; GeneCards: SV2B; OMA:SV2B - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	91,302,565 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	74,959,010 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 10; ; Brodmann area 23; ; frontal pole; ; Brodmann area 46; ; orbitofrontal cortex; ; paraflocculus of cerebellum; ; superior frontal gyrus; ; pons; ; postcentral gyrus;
	Top expressed in
	subiculum; ; piriform cortex; ; prefrontal cortex; ; primary motor cortex; ; dentate gyrus of hippocampal formation granule cell; ; temporal lobe; ; amygdala; ; cingulate gyrus; ; hippocampus proper; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; transmembrane transporter activity; transporter activity;
Cellular component	cell junction; plasma membrane; synapse; acrosomal vesicle; membrane; cytoplasmic vesicle; synaptic vesicle; integral component of membrane; synaptic vesicle membrane; neuron projection;
Biological process	neurotransmitter transport; transmembrane transport; chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	9899
	64176
	ENSG00000185518
	ENSMUSG00000053025
	Q7L1I2
	Q8BG39
NM_001167580; NM_014848; NM_001323031; NM_001323032; NM_001323033;
	NM_001323034; NM_001323036; NM_001323037; NM_001323038; NM_001323039; NM_001323040
NM_001109753; NM_153579; NM_001360571; NM_001360572; NM_001360573;
	NM_001360574; NM_001360575
NP_001161052; NP_001309960; NP_001309961; NP_001309962; NP_001309963;
	NP_001309965; NP_001309966; NP_001309967; NP_001309968; NP_001309969; NP_055663
NP_001103223; NP_705807; NP_001347500; NP_001347501; NP_001347502;
	NP_001347503; NP_001347504
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptic vesicle glycoprotein 2B is a protein that in humans is encoded by the SV2B gene.⁵⁶⁷

References

GRCh38: Ensembl release 89: ENSG00000185518 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000053025 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
Bajjalieh SM, Peterson K, Linial M, Scheller RH (Apr 1993). "Brain contains two forms of synaptic vesicle protein 2". Proc Natl Acad Sci U S A. 90 (6): 2150–4. Bibcode:1993PNAS...90.2150B. doi:10.1073/pnas.90.6.2150. PMC 46043. PMID 7681585.
"Entrez Gene: SV2B synaptic vesicle glycoprotein 2B".

Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lazzell DR, Belizaire R, Thakur P, et al. (2005). "SV2B regulates synaptotagmin 1 by direct interaction". J. Biol. Chem. 279 (50): 52124–31. doi:10.1074/jbc.M407502200. PMID 15466855.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Janz R, Goda Y, Geppert M, et al. (2000). "SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release". Neuron. 24 (4): 1003–16. doi:10.1016/S0896-6273(00)81046-6. PMID 10624962.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185518 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053025 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9872452-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.

[pmid7681585-6] Bajjalieh SM, Peterson K, Linial M, Scheller RH (Apr 1993). "Brain contains two forms of synaptic vesicle protein 2". Proc Natl Acad Sci U S A. 90 (6): 2150–4. Bibcode:1993PNAS...90.2150B. doi:10.1073/pnas.90.6.2150. PMC 46043. PMID 7681585.

[entrez-7] "Entrez Gene: SV2B synaptic vesicle glycoprotein 2B".

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See also

References

Further reading