Article · Wikipedia archive · Last revised Jun 7, 2026

Suprofen

Suprofen is a nonsteroidal anti-inflammatory drug (NSAID) developed by Janssen Pharmaceutica that was marketed as 1% eye drops under the trade name Profenal.

Last revised
Jun 7, 2026
Read time
≈ 1 min
Length
221 w
Citations
4
Source
Wikipedia ↗
Suprofen
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration		Oral, eye drops
ATC code
Legal status
Legal status
  • Discontinued
Pharmacokinetic data
Protein binding20%
Identifiers
  • (RS)-2-[4-(2-thienylcarbonyl)phenyl]propanoic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.050.071
Chemical and physical data
FormulaC14H12O3S
Molar mass260.31 g·mol−1
3D model (JSmol)
  • O=C(c1ccc(cc1)C(C(=O)O)C)c2sccc2
  • InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17) ☒N
  • Key:MDKGKXOCJGEUJW-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Suprofen is a nonsteroidal anti-inflammatory drug (NSAID) developed by Janssen Pharmaceutica1 that was marketed as 1% eye drops under the trade name Profenal.

Uses

Suprofen was originally used as tablet, but oral uses have been discontinued due to renal effects.2 It was subsequently used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic surgery.3 This application has been discontinued as well, at least in the US.4

References

References

  1. DE 2353357, Janssen PA, Van Daele GH, Boey JM, "Antiphlogistic aroyl-substituted phenylacetic acid derivatives", issued 1974 
  2. Nies AS (1988). "Renal Effects of Nonsteroidal Anti-Inflammatory Drugs". Basis for Variability of Response to Anti-Rheumatic Drugs. Vol. 24. pp. 95–106. doi:10.1007/978-3-0348-9160-8_9 (inactive 12 July 2025). ISBN 978-3-0348-9931-4. PMID 3142236. {{cite book}}: |journal= ignored (help)CS1 maint: DOI inactive as of July 2025 (link)
  3. "Pharmacy Compounding". Guidance for FDA Staff and Industry Compliance Policy Guides Manual. U.S. Food and Drug Administration. Archived from the original on 1 January 2009.
  4. "Suprofen ophthalmic". Drugs.com. Archived from the original on 2021-09-09. Retrieved 2018-01-23.