Suloctidil

Suloctidil
Clinical data
ATC code	C04AX19 (WHO) ;
Identifiers
	IUPAC name 1-[4-(isopropylthio)phenyl]-2-(octylamino)propan-1-ol;
CAS Number	54767-75-8 Y;
PubChem CID	5354;
ChemSpider	571402;
UNII	XV1N1XY17K;
ChEBI	CHEBI:233445;
ChEMBL	ChEMBL588119;
CompTox Dashboard (EPA)	DTXSID701017974 DTXSID4045638, DTXSID701017974 ;
ECHA InfoCard	100.053.920
Chemical and physical data
Formula	C20H35NOS
Molar mass	337.57 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCCCCNC(C)C(C1=CC=C(C=C1)SC(C)C)O;
	InChI InChI=1S/C20H35NOS/c1-5-6-7-8-9-10-15-21-17(4)20(22)18-11-13-19(14-12-18)23-16(2)3/h11-14,16-17,20-22H,5-10,15H2,1-4H3; Key:BFCDFTHTSVTWOG-UHFFFAOYSA-N;
	(verify)

Suloctidil was a sulfur-containing aminoalcohol that was brought to market in the early 1970s as a vasodilator by Continental Pharma, a Belgian company.¹^{: 118–121}²³

Continental was bought by Monsanto in 1984, primarily on the promise of sales of suloctidil, which was approved in Europe at the time, but not in the US.⁴ However, in 1985 Monsanto halted development and withdrew the drug worldwide following reports of liver toxicity.⁵^: 251

References

Hladovec J (1989). Antithrombotic Drugs in Thrombosis Models. CRC Press. ISBN 978-0-8493-5162-4.
Roncucci R, Roba J, Lambelin G, Ferenczi M, Blaton V, Vandamme D, Peeters H (March 1975). "Potential antilipolytic activity of suloctidil". Die Naturwissenschaften. 62 (3): 141–2. Bibcode:1975NW.....62..141R. doi:10.1007/bf00623284. PMID 1240601. S2CID 29484315.
BE granted 739678, Buu-Hoi NP, Lambelin G, Roba J, Jacques G, Gillet C, "1-Subst-phenyl-2-amino-ethanols useful as beta adrenergic agents peripheral vasodilators and hypotensive agents"
"Monsanto's $150 mil. Life Sciences Research Center". Pharma & Medteck Business Intelligence. 5 November 1984. Archived from the original on 2015-07-07.
"Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or not Approved by Governments Twelfth Issue: Pharmaceuticals" (PDF). Department of Economic and Social Affairs of the United Nations Secretariat. New York: United Nations. 2005.

[1] Hladovec J (1989). Antithrombotic Drugs in Thrombosis Models. CRC Press. ISBN 978-0-8493-5162-4.

[pmid1240601-2] Roncucci R, Roba J, Lambelin G, Ferenczi M, Blaton V, Vandamme D, Peeters H (March 1975). "Potential antilipolytic activity of suloctidil". Die Naturwissenschaften. 62 (3): 141–2. Bibcode:1975NW.....62..141R. doi:10.1007/bf00623284. PMID 1240601. S2CID 29484315.

[3] BE granted 739678, Buu-Hoi NP, Lambelin G, Roba J, Jacques G, Gillet C, "1-Subst-phenyl-2-amino-ethanols useful as beta adrenergic agents peripheral vasodilators and hypotensive agents"

[4] "Monsanto's $150 mil. Life Sciences Research Center". Pharma & Medteck Business Intelligence. 5 November 1984. Archived from the original on 2015-07-07.

[5] "Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or not Approved by Governments Twelfth Issue: Pharmaceuticals" (PDF). Department of Economic and Social Affairs of the United Nations Secretariat. New York: United Nations. 2005.

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Clinical data

ATC code	C04AX19 (WHO)
Identifiers
IUPAC name 1-[4-(isopropylthio)phenyl]-2-(octylamino)propan-1-ol
CAS Number	54767-75-8^Y
PubChem CID	5354
ChemSpider	571402
UNII	XV1N1XY17K
ChEBI	CHEBI:233445
ChEMBL	ChEMBL588119
CompTox Dashboard (EPA)	DTXSID701017974 DTXSID4045638, DTXSID701017974
ECHA InfoCard	100.053.920
Chemical and physical data
Formula	C₂₀H₃₅NOS
Molar mass	337.57 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCCCCCCCNC(C)C(C1=CC=C(C=C1)SC(C)C)O
InChI InChI=1S/C20H35NOS/c1-5-6-7-8-9-10-15-21-17(4)20(22)18-11-13-19(14-12-18)23-16(2)3/h11-14,16-17,20-22H,5-10,15H2,1-4H3 Key:BFCDFTHTSVTWOG-UHFFFAOYSA-N
(verify)