SUDS3

SUDS3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2N2H, 4ZQA
Identifiers
Aliases	SUDS3, SAP45, SDS3, SDS3 homolog, SIN3A corepressor complex component
External IDs	OMIM: 608250; MGI: 1919204; HomoloGene: 15906; GeneCards: SUDS3; OMA:SUDS3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	118,418,033 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	117,254,178 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; buccal mucosa cell; ; palpebral conjunctiva; ; pancreatic epithelial cell; ; epithelium of colon; ; parotid gland; ; skin of arm; ; tonsil; ; germinal epithelium; ; bone marrow cell;
	Top expressed in
	spermatid; ; spermatocyte; ; saccule; ; neural layer of retina; ; blood; ; otic placode; ; otic vesicle; ; granulocyte; ; lens; ; lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	histone deacetylase binding; protein binding; enzyme binding; histone deacetylase activity;
Cellular component	Sin3 complex; nucleoplasm; Sin3-type complex; nucleus; cytosol; nuclear body;
Biological process	regulation of transcription, DNA-templated; substantia nigra development; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of apoptotic process; negative regulation of transcription, DNA-templated; histone deacetylation; apoptotic process; protein deubiquitination; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	64426
	71954
	ENSG00000111707
	ENSMUSG00000066900
	Q9H7L9
	Q8BR65
	NM_022491
	NM_001122666; NM_178622
	NP_071936
	NP_001116138; NP_848737
	Wikidata
View/Edit Human	View/Edit Mouse

Sin3 histone deacetylase corepressor complex component SDS3 is an enzyme that in humans is encoded by the SUDS3 gene.⁵⁶

Function

SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003).[supplied by OMIM]⁶

Interactions

SUDS3 has been shown to interact with HDAC1,⁵⁷ Host cell factor C1,⁸ SIN3B⁵ and SIN3A.⁵⁷

References

GRCh38: Ensembl release 89: ENSG00000111707 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000066900 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA (April 2002). "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex". Molecular and Cellular Biology. 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. PMC 133736. PMID 11909966.
"Entrez Gene: SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)".
Fleischer TC, Yun UJ, Ayer DE (May 2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Molecular and Cellular Biology. 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. PMC 164750. PMID 12724404.
Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W (April 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes & Development. 17 (7): 896–911. doi:10.1101/gad.252103. PMC 196026. PMID 12670868.

Further reading

Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Fleischer TC, Yun UJ, Ayer DE (May 2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Molecular and Cellular Biology. 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. PMC 164750. PMID 12724404.
Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W (April 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes & Development. 17 (7): 896–911. doi:10.1101/gad.252103. PMC 196026. PMID 12670868.
Hattori A, Okumura K, Nagase T, Kikuno R, Hirosawa M, Ohara O (December 2000). "Characterization of long cDNA clones from human adult spleen". DNA Research. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111707 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000066900 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11909966-5] Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA (April 2002). "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex". Molecular and Cellular Biology. 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. PMC 133736. PMID 11909966.

[entrez-6] "Entrez Gene: SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)".

[pmid12724404-7] Fleischer TC, Yun UJ, Ayer DE (May 2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Molecular and Cellular Biology. 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. PMC 164750. PMID 12724404.

[pmid12670868-8] Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W (April 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes & Development. 17 (7): 896–911. doi:10.1101/gad.252103. PMC 196026. PMID 12670868.

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