STX7

STX7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GL2
Identifiers
Aliases	STX7, syntaxin 7
External IDs	OMIM: 603217; MGI: 1858210; HomoloGene: 37823; GeneCards: STX7; OMA:STX7 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	132,513,198 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	24,066,120 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; monocyte; ; tendon of biceps brachii; ; Achilles tendon; ; middle temporal gyrus; ; ganglionic eminence; ; amniotic fluid; ; internal globus pallidus; ; glomerulus; ; secondary oocyte;
	Top expressed in
	yolk sac; ; dentate gyrus of hippocampal formation granule cell; ; submandibular gland; ; stroma of bone marrow; ; right kidney; ; trigeminal ganglion; ; granulocyte; ; conjunctival fornix; ; barrel cortex; ; substantia nigra;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	SNAP receptor activity; protein binding; chloride channel inhibitor activity; syntaxin binding; SNARE binding;
Cellular component	integral component of membrane; recycling endosome; vesicle; endosome; late endosome; early endosome membrane; membrane; tertiary granule; plasma membrane; endocytic vesicle; lysosomal membrane; SNARE complex; azurophil granule; early endosome; immunological synapse; perinuclear region of cytoplasm; lysosome; extracellular exosome; synaptic vesicle; endomembrane system;
Biological process	positive regulation of receptor localization to synapse; organelle localization; positive regulation of T cell mediated cytotoxicity; vesicle docking; organelle assembly; intracellular protein transport; vesicle fusion; vesicle-mediated transport; regulation of protein localization to plasma membrane; regulation of molecular function;
	Sources:Amigo / QuickGO
Orthologs
	8417
	53331
	ENSG00000079950
	ENSMUSG00000019998
	O15400
	O70439; Q8BH40
	NM_003569; NM_001326578; NM_001326579; NM_001326580
	NM_016797; NM_001358563
	NP_001313507; NP_001313508; NP_001313509; NP_003560
	NP_058077; NP_001345492
	Wikidata
View/Edit Human	View/Edit Mouse

Syntaxin-7 is a protein that in humans is encoded by the STX7 gene.⁵⁶

In melanocytic cells STX7 gene expression may be regulated by MITF.⁷

Interactions

STX7 has been shown to interact with STX8,⁸ VPS18,⁹ Vesicle-associated membrane protein 8⁸¹⁰ and VPS11.⁹

References

GRCh38: Ensembl release 89: ENSG00000079950 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000019998 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wang H, Frelin L, Pevsner J (October 1997). "Human syntaxin 7: a Pep12p/Vps6p homologue implicated in vesicle trafficking to lysosomes". Gene. 199 (1–2): 39–48. doi:10.1016/S0378-1119(97)00343-0. PMID 9358037.
"Entrez Gene: STX7 syntaxin 7".
Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (December 2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". The EMBO Journal. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC 305878. PMID 11101518.
Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C (August 2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". The Journal of Biological Chemistry. 276 (31): 29393–402. doi:10.1074/jbc.M101778200. PMID 11382755.
Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE (June 2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". The Journal of Biological Chemistry. 276 (23): 19820–7. doi:10.1074/jbc.M010838200. PMID 11278762.

Further reading

Wong SH, Xu Y, Zhang T, Hong W (January 1998). "Syntaxin 7, a novel syntaxin member associated with the early endosomal compartment". The Journal of Biological Chemistry. 273 (1): 375–80. doi:10.1074/jbc.273.1.375. PMID 9417091.
Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (December 1998). "Three novel proteins of the syntaxin/SNAP-25 family". The Journal of Biological Chemistry. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
Prekeris R, Yang B, Oorschot V, Klumperman J, Scheller RH (November 1999). "Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking". Molecular Biology of the Cell. 10 (11): 3891–908. doi:10.1091/mbc.10.11.3891. PMC 25687. PMID 10564279.
Nakamura N, Yamamoto A, Wada Y, Futai M (March 2000). "Syntaxin 7 mediates endocytic trafficking to late endosomes". The Journal of Biological Chemistry. 275 (9): 6523–9. doi:10.1074/jbc.275.9.6523. PMID 10692457.
Scales SJ, Chen YA, Yoo BY, Patel SM, Doung YC, Scheller RH (May 2000). "SNAREs contribute to the specificity of membrane fusion". Neuron. 26 (2): 457–64. doi:10.1016/S0896-6273(00)81177-0. PMID 10839363.
Mullock BM, Smith CW, Ihrke G, Bright NA, Lindsay M, Parkinson EJ, Brooks DA, Parton RG, James DE, Luzio JP, Piper RC (September 2000). "Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and Is required for late endosome-lysosome fusion". Molecular Biology of the Cell. 11 (9): 3137–53. doi:10.1091/mbc.11.9.3137. PMC 14981. PMID 10982406.
Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (December 2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". The EMBO Journal. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC 305878. PMID 11101518.
Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE (June 2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". The Journal of Biological Chemistry. 276 (23): 19820–7. doi:10.1074/jbc.M010838200. PMID 11278762.
Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C (August 2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". The Journal of Biological Chemistry. 276 (31): 29393–402. doi:10.1074/jbc.M101778200. PMID 11382755.
Rotem-Yehudar R, Galperin E, Horowitz M (August 2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29". The Journal of Biological Chemistry. 276 (35): 33054–60. doi:10.1074/jbc.M009913200. PMID 11423532.
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (October 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
Antonin W, Fasshauer D, Becker S, Jahn R, Schneider TR (February 2002). "Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs". Nature Structural Biology. 9 (2): 107–11. doi:10.1038/nsb746. hdl:11858/00-001M-0000-0012-F459-F. PMID 11786915. S2CID 17724790.
Antonin W, Dulubova I, Arac D, Pabst S, Plitzner J, Rizo J, Jahn R (September 2002). "The N-terminal domains of syntaxin 7 and vti1b form three-helix bundles that differ in their ability to regulate SNARE complex assembly". The Journal of Biological Chemistry. 277 (39): 36449–56. doi:10.1074/jbc.M204369200. hdl:11858/00-001M-0000-0012-F2E6-3. PMID 12114520.
Bogdanovic A, Bennett N, Kieffer S, Louwagie M, Morio T, Garin J, Satre M, Bruckert F (November 2002). "Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum". The Biochemical Journal. 368 (Pt 1): 29–39. doi:10.1042/BJ20020845. PMC 1222979. PMID 12175335.
Collins RF, Schreiber AD, Grinstein S, Trimble WS (September 2002). "Syntaxins 13 and 7 function at distinct steps during phagocytosis". Journal of Immunology. 169 (6): 3250–6. doi:10.4049/jimmunol.169.6.3250. PMID 12218144.
Adkins JN, Varnum SM, Auberry KJ, Moore RJ, Angell NH, Smith RD, Springer DL, Pounds JG (December 2002). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Molecular & Cellular Proteomics. 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Suzuki J, Ohnishi H, Wada A, Hirayama T, Ohno H, Ueda N, Yasuda H, Iiri T, Wada Y, Futai M, Mashima H (July 2003). "Involvement of syntaxin 7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori-produced cytotoxin VacA". The Journal of Biological Chemistry. 278 (28): 25585–90. doi:10.1074/jbc.M212445200. PMID 12730232.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000079950 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019998 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9358037-5] Wang H, Frelin L, Pevsner J (October 1997). "Human syntaxin 7: a Pep12p/Vps6p homologue implicated in vesicle trafficking to lysosomes". Gene. 199 (1–2): 39–48. doi:10.1016/S0378-1119(97)00343-0. PMID 9358037.

[entrez-6] "Entrez Gene: STX7 syntaxin 7".

[pmid19067971-7] Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

[pmid11101518-8] Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (December 2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". The EMBO Journal. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC 305878. PMID 11101518.

[pmid11382755-9] Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C (August 2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". The Journal of Biological Chemistry. 276 (31): 29393–402. doi:10.1074/jbc.M101778200. PMID 11382755.

[pmid11278762-10] Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE (June 2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". The Journal of Biological Chemistry. 276 (23): 19820–7. doi:10.1074/jbc.M010838200. PMID 11278762.

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