| SprX sRNA | |
|---|---|
 Predicted secondary structure and sequence conservation of SprX small RNA | |
| Identifiers | |
| Rfam | RF02672 |
| Other data | |
| Domain | Bacteria |
| GO | GO:0040033 |
| SO | SO:0000370 |
| PDB structures | PDBe |
In molecular biology the small pathogenicity island RNA X (alias RsaOR) gene is a bacterial non-coding RNA. It was discovered in a large-scale analysis of Staphylococcus aureus.1 SprX was shown to influence antibiotic resistance of the bacteria to Vancomycin and Teicoplanin glycopeptides, which are used to treat MRSA infections.2 In this study the authors identified a SprX target, stage V sporulation protein G (Spo VG). By reducing Spo VG expression levels, SprX affects S. aureus resistance to the glycopeptide antibiotics. Further work demonstrated its involvement in the regulation of pathogenicity factors.3
References
References
- Bohn C, Rigoulay C, Chabelskaya S, Sharma CM, Marchais A, Skorski P, Borezée-Durant E, Barbet R, Jacquet E, Jacq A, Gautheret D, Felden B, Vogel J, Bouloc P (October 2010). "Experimental discovery of small RNAs in Staphylococcus aureus reveals a riboregulator of central metabolism". Nucleic Acids Research. 38 (19): 6620–36. doi:10.1093/nar/gkq462. PMC 2965222. PMID 20511587.
- Eyraud A, Tattevin P, Chabelskaya S, Felden B (April 2014). "A small RNA controls a protein regulator involved in antibiotic resistance in Staphylococcus aureus". Nucleic Acids Research. 42 (8): 4892–905. doi:10.1093/nar/gku149. PMC 4005690. PMID 24557948.
- Kathirvel M, Buchad H, Nair M (December 2016). "Enhancement of the pathogenicity of Staphylococcus aureus strain Newman by a small noncoding RNA SprX1". Medical Microbiology and Immunology. 205 (6): 563–574. doi:10.1007/s00430-016-0467-9. PMID 27438010. S2CID 15284645.