SPRED2

SPRED2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JP2
Identifiers
Aliases	SPRED2, Spred-2, sprouty related EVH1 domain containing 2, NS14
External IDs	OMIM: 609292; MGI: 2150019; HomoloGene: 24918; GeneCards: SPRED2; OMA:SPRED2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	65,432,637 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	19,974,026 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; mucosa of sigmoid colon; ; ventricular zone; ; cartilage tissue; ; epithelium of colon; ; gonad; ; postcentral gyrus; ; prefrontal cortex; ; superior frontal gyrus; ; Brodmann area 46;
	Top expressed in
	tail of embryo; ; primitive streak; ; prefrontal cortex; ; cingulate gyrus; ; genital tubercle; ; hair follicle; ; primary motor cortex; ; hippocampus proper; ; cerebellar vermis; ; lobe of cerebellum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein kinase binding; protein serine/threonine kinase inhibitor activity; stem cell factor receptor binding;
Cellular component	cytoplasm; plasma membrane; transport vesicle membrane; membrane; cytoplasmic vesicle; cytosol;
Biological process	multicellular organism development; negative regulation of peptidyl-threonine phosphorylation; regulation of signal transduction; fibroblast growth factor receptor signaling pathway; regulation of protein deacetylation; positive regulation of DNA damage response, signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	200734
	114716
	ENSG00000198369
	ENSMUSG00000045671
	Q7Z698
	Q924S7
	NM_001128210; NM_181784
	NM_033523
	NP_001121682; NP_861449
	NP_277058
	Wikidata
View/Edit Human	View/Edit Mouse

Sprouty-related, EVH1 domain-containing protein 2 is a protein that in humans is encoded by the SPRED2 gene.⁵

Function

SPRED2 is a member of the Sprouty (see SPRY1)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1⁵).

References

GRCh38: Ensembl release 89: ENSG00000198369 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000045671 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: SPRED2 sprouty-related, EVH1 domain containing 2".

Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Wakioka T, Sasaki A, Kato R, et al. (2001). "Spred is a Sprouty-related suppressor of Ras signalling". Nature. 412 (6847): 647–51. Bibcode:2001Natur.412..647W. doi:10.1038/35088082. PMID 11493923. S2CID 4345140.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kato R, Nonami A, Taketomi T, et al. (2003). "Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation". Biochem. Biophys. Res. Commun. 302 (4): 767–72. doi:10.1016/S0006-291X(03)00259-6. PMID 12646235.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Nobuhisa I, Kato R, Inoue H, et al. (2004). "Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation". J. Exp. Med. 199 (5): 737–42. doi:10.1084/jem.20030830. PMC 2213301. PMID 14981116.
Miyoshi K, Wakioka T, Nishinakamura H, et al. (2004). "The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization". Oncogene. 23 (33): 5567–76. doi:10.1038/sj.onc.1207759. PMID 15184877.
Zimmermann J, Jarchau T, Walter U, et al. (2005). "1H, 13C and 15N resonance assignment of the human Spred2 EVH1 domain". J. Biomol. NMR. 29 (3): 435–6. doi:10.1023/B:JNMR.0000032526.17586.8c. PMID 15213456. S2CID 37933714.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Engelhardt CM, Bundschu K, Messerschmitt M, et al. (2005). "Expression and subcellular localization of Spred proteins in mouse and human tissues". Histochem. Cell Biol. 122 (6): 527–38. doi:10.1007/s00418-004-0725-6. PMID 15580519. S2CID 24496085.
King JA, Straffon AF, D'Abaco GM, et al. (2005). "Distinct requirements for the Sprouty domain for functional activity of Spred proteins". Biochem. J. 388 (Pt 2): 445–54. doi:10.1042/BJ20041284. PMC 1138951. PMID 15683364.
Bundschu K, Knobeloch KP, Ullrich M, et al. (2005). "Gene disruption of Spred-2 causes dwarfism". J. Biol. Chem. 280 (31): 28572–80. doi:10.1074/jbc.M503640200. PMID 15946934.
Yoshida T, Hisamoto T, Akiba J, et al. (2006). "Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors". Oncogene. 25 (45): 6056–66. doi:10.1038/sj.onc.1209635. PMID 16652141.
Lock P, I ST, Straffon AF, et al. (2007). "Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination". Biochem. Biophys. Res. Commun. 351 (4): 1018–23. doi:10.1016/j.bbrc.2006.10.150. PMID 17094949.

External links

GeneReviews/NIH/NCBI/UW entry on Legius syndrome SPRED1 Sprouty-related, EVH1 domain-containing protein 1

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198369 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045671 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SPRED2 sprouty-related, EVH1 domain containing 2".

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