Sperm-associated antigen 5

SPAG5
Identifiers
Aliases	SPAG5, DEEPEST, MAP126, hMAP126, Sperm associated antigen 5
External IDs	OMIM: 615562; MGI: 1927470; HomoloGene: 4718; GeneCards: SPAG5; OMA:SPAG5 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,599,025 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,213,283 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; ventricular zone; ; gonad; ; ganglionic eminence; ; mucosa of transverse colon; ; testicle; ; right lobe of liver; ; right lobe of thyroid gland; ; human kidney;
	Top expressed in
	epithelium of lens; ; spermatocyte; ; ventricular zone; ; spermatid; ; tail of embryo; ; lumbar subsegment of spinal cord; ; seminiferous tubule; ; epiblast; ; genital tubercle; ; mandibular prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; microtubule binding;
Cellular component	spindle; mitotic spindle; chromosome; microtubule organizing center; centriolar satellite; spindle pole; chromosome, centromeric region; microtubule plus-end; midbody; microtubule; kinetochore; cytoskeleton; cytoplasm; mitotic spindle pole; spindle microtubule;
Biological process	mitotic sister chromatid segregation; cell cycle; spindle organization; cell division; protein localization to centrosome; chromosome segregation; regulation of attachment of spindle microtubules to kinetochore; positive regulation of intracellular transport; regulation of metaphase plate congression; positive regulation of spindle assembly; establishment of spindle orientation;
	Sources:Amigo / QuickGO
Orthologs
	10615
	54141
	ENSG00000076382
	ENSMUSG00000002055
	Q96R06
	Q7TME2
	NM_006461
	NM_017407
	NP_006452
	NP_059103
	Wikidata
View/Edit Human	View/Edit Mouse

Sperm-associated antigen 5 is a protein that in humans is encoded by the SPAG5 gene.⁵⁶

This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles.⁶

References

GRCh38: Ensembl release 89: ENSG00000076382 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000002055 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Chang MS, Huang CJ, Chen ML, Chen ST, Fan CC, Chu JM, Lin WC, Yang YC (Sep 2001). "Cloning and characterization of hMAP126, a new member of mitotic spindle-associated proteins". Biochem Biophys Res Commun. 287 (1): 116–21. doi:10.1006/bbrc.2001.5554. PMID 11549262.
"Entrez Gene: SPAG5 sperm associated antigen 5".

Further reading

Howard L, Nelson KK, Maciewicz RA, Blobel CP (1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. PMID 10531379.
Shao X, Xue J, van der Hoorn FA (2001). "Testicular protein Spag5 has similarity to mitotic spindle protein Deepest and binds outer dense fiber protein Odf1". Mol. Reprod. Dev. 59 (4): 410–6. doi:10.1002/mrd.1047. PMID 11468777. S2CID 13590694.
Mack GJ, Compton DA (2002). "Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated protein". Proc. Natl. Acad. Sci. U.S.A. 98 (25): 14434–9. doi:10.1073/pnas.261371298. PMC 64699. PMID 11724960.
Gruber J, Harborth J, Schnabel J, et al. (2003). "The mitotic-spindle-associated protein astrin is essential for progression through mitosis". J. Cell Sci. 115 (Pt 21): 4053–9. doi:10.1242/jcs.00088. hdl:11858/00-001M-0000-0012-F29B-B. PMID 12356910.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Le XF, Lammayot A, Gold D, et al. (2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". J. Biol. Chem. 280 (3): 2092–104. doi:10.1074/jbc.M403080200. PMID 15504738.
Yang YC, Hsu YT, Wu CC, et al. (2006). "Silencing of astrin induces the p53-dependent apoptosis by suppression of HPV18 E6 expression and sensitizes cells to paclitaxel treatment in HeLa cells" (PDF). Biochem. Biophys. Res. Commun. 343 (2): 428–34. doi:10.1016/j.bbrc.2006.02.166. PMID 16546135.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Cheng TS, Hsiao YL, Lin CC, et al. (2007). "hNinein is required for targeting spindle-associated protein Astrin to the centrosome during the S and G2 phases" (PDF). Exp. Cell Res. 313 (8): 1710–21. doi:10.1016/j.yexcr.2007.02.023. PMID 17383637.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000076382 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002055 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11549262-5] Chang MS, Huang CJ, Chen ML, Chen ST, Fan CC, Chu JM, Lin WC, Yang YC (Sep 2001). "Cloning and characterization of hMAP126, a new member of mitotic spindle-associated proteins". Biochem Biophys Res Commun. 287 (1): 116–21. doi:10.1006/bbrc.2001.5554. PMID 11549262.

[entrez-6] "Entrez Gene: SPAG5 sperm associated antigen 5".

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