Spectrin repeat containing nuclear envelope family member 3

SYNE3
Identifiers
Aliases	SYNE3, C14orf49, NET53, Nesp3, spectrin repeat containing nuclear envelope family member 3, C14orf139, KASH3, LINC00341, NCRNA00341
External IDs	OMIM: 610861; MGI: 2442408; HomoloGene: 17625; GeneCards: SYNE3; OMA:SYNE3 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	95,516,650 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	104,976,068 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; parietal pleura; ; synovial membrane; ; trabecular bone; ; synovial joint; ; skin of hip; ; visceral pleura; ; superficial temporal artery; ; pericardium; ; skin of thigh;
	Top expressed in
	neural layer of retina; ; granulocyte; ; zygote; ; lip; ; embryo; ; thymus; ; endothelial cell of lymphatic vessel; ; esophagus; ; embryo; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	actin filament binding; protein binding; cytoskeletal protein binding;
Cellular component	integral component of membrane; rough endoplasmic reticulum; nuclear outer membrane; nuclear envelope; membrane; meiotic nuclear membrane microtubule tethering complex; nucleus; endoplasmic reticulum; nuclear membrane; cytoplasm;
Biological process	establishment of protein localization to membrane; cytoskeleton organization; regulation of cell shape; nuclear migration; nucleus localization;
	Sources:Amigo / QuickGO
Orthologs
	161176
	212073
	ENSG00000176438
	ENSMUSG00000054150
	Q6ZMZ3
	Q4FZC9
NM_024633; NM_152592; NM_001363692; NM_001384281; NM_001384282;
	NM_001384283; NM_001384284
	NM_001042699; NM_172500
	NP_689805; NP_001350621
	NP_001036164; NP_766088; NP_001390387
	Wikidata
View/Edit Human	View/Edit Mouse

Spectrin repeat containing nuclear envelope family member 3, or Nesprin-3, is a Nesprin-family protein that in humans is encoded by the SYNE3 gene.⁵ Nesprin-3 localizes to the outer nuclear membrane, where it is retained by SUN domain-containing proteins. The n-terminus of Nesprin-3 faces the cytoplasm and associates with the cytolinker protein Plectin.⁶

References

GRCh38: Ensembl release 89: ENSG00000176438 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000054150 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Spectrin repeat containing nuclear envelope family member 3". Retrieved 2018-05-27.
Wilhelmsen K, Litjens SH, Kuikman I, Tshimbalanga N, Janssen H, van den Bout I, et al. (December 2005). "Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin". The Journal of Cell Biology. 171 (5): 799–810. doi:10.1083/jcb.200506083. PMC 2171291. PMID 16330710.

Further reading

Nery FC, Zeng J, Niland BP, Hewett J, Farley J, Irimia D, et al. (October 2008). "TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton". Journal of Cell Science. 121 (Pt 20): 3476–3486. doi:10.1242/jcs.029454. PMC 3539201. PMID 18827015.
Morgan JT, Pfeiffer ER, Thirkill TL, Kumar P, Peng G, Fridolfsson HN, et al. (November 2011). "Nesprin-3 regulates endothelial cell morphology, perinuclear cytoskeletal architecture, and flow-induced polarization". Molecular Biology of the Cell. 22 (22): 4324–4334. doi:10.1091/mbc.E11-04-0287. PMC 3216658. PMID 21937718.
Liao M, Li B, Zhang S, Liu Q, Liao W, Xie W, Zhang Y (February 2017). "Relationship between LINC00341 expression and cancer prognosis". Oncotarget. 8 (9): 15283–15293. doi:10.18632/oncotarget.14843. PMC 5362486. PMID 28146429.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000176438 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054150 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Spectrin repeat containing nuclear envelope family member 3". Retrieved 2018-05-27.

[Wilhelmsen_et_al-6] Wilhelmsen K, Litjens SH, Kuikman I, Tshimbalanga N, Janssen H, van den Bout I, et al. (December 2005). "Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin". The Journal of Cell Biology. 171 (5): 799–810. doi:10.1083/jcb.200506083. PMC 2171291. PMID 16330710.

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