SNX4

SNX4
Identifiers
Aliases	SNX4, ATG24B, sorting nexin 4
External IDs	OMIM: 605931; MGI: 1916400; HomoloGene: 36143; GeneCards: SNX4; OMA:SNX4 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	125,520,202 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	33,120,639 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; jejunal mucosa; ; Achilles tendon; ; kidney tubule; ; ganglionic eminence; ; ventricular zone; ; islet of Langerhans; ; duodenum; ; Epithelium of choroid plexus; ; tendon of biceps brachii;
	Top expressed in
	atrioventricular valve; ; left lung lobe; ; endocardial cushion; ; sciatic nerve; ; granulocyte; ; yolk sac; ; vestibular sensory epithelium; ; ureter; ; primitive streak; ; zygote;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	insulin receptor binding; leptin receptor binding; epidermal growth factor receptor binding; protein binding; phosphatidylinositol binding; transferrin receptor binding; lipid binding;
Cellular component	cytoplasm; extrinsic component of membrane; endosome; early endosome membrane; membrane; plasma membrane; SNARE complex; cytoplasmic dynein complex; protein-containing complex; early endosome;
Biological process	endocytosis; vesicle organization; endocytic recycling; protein transport; positive regulation of histamine secretion by mast cell;
	Sources:Amigo / QuickGO
Orthologs
	8723
	69150
	ENSG00000114520
	ENSMUSG00000022808
	O95219
	Q91YJ2
	NM_003794
	NM_080557
	NP_003785
	NP_542124
	Wikidata
View/Edit Human	View/Edit Mouse

Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.⁵⁶

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.⁶

Interactions

SNX4 has been shown to interact with BIN1.⁷

References

GRCh38: Ensembl release 89: ENSG00000114520 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022808 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Mol Cell Biol. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC 109309. PMID 9819414.
"Entrez Gene: SNX4 sorting nexin 4".
Leprince, Corinne; Le Scolan Erwan; Meunier Brigitte; Fraisier Vincent; Brandon Nathalie; De Gunzburg Jean; Camonis Jacques (May 2003). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking". J. Cell Sci. 116 (Pt 10). England: 1937–48. doi:10.1242/jcs.00403. ISSN 0021-9533. PMID 12668730.

Further reading

Traer CJ, Rutherford AC, Palmer KJ, et al. (2008). "SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment". Nat. Cell Biol. 9 (12): 1370–80. doi:10.1038/ncb1656. PMID 17994011. S2CID 23816176.
Skånland SS, Wälchli S, Utskarpen A, et al. (2007). "Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins". Traffic. 8 (3): 297–309. doi:10.1111/j.1600-0854.2006.00527.x. hdl:10852/11339. PMID 17319803. S2CID 21600584.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Leprince C, Le Scolan E, Meunier B, et al. (2004). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking". J. Cell Sci. 116 (Pt 10): 1937–48. doi:10.1242/jcs.00403. PMID 12668730.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Parks WT, Frank DB, Huff C, et al. (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". J. Biol. Chem. 276 (22): 19332–9. doi:10.1074/jbc.M100606200. PMID 11279102.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000114520 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022808 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9819414-5] Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Mol Cell Biol. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC 109309. PMID 9819414.

[entrez-6] "Entrez Gene: SNX4 sorting nexin 4".

[pmid12668730-7] Leprince, Corinne; Le Scolan Erwan; Meunier Brigitte; Fraisier Vincent; Brandon Nathalie; De Gunzburg Jean; Camonis Jacques (May 2003). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking". J. Cell Sci. 116 (Pt 10). England: 1937–48. doi:10.1242/jcs.00403. ISSN 0021-9533. PMID 12668730.

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