SLU7

SLU7
Identifiers
Aliases	SLU7, 9G8, hSlu7, SLU7 homolog, splicing factor
External IDs	OMIM: 605974; MGI: 2385598; HomoloGene: 4690; GeneCards: SLU7; OMA:SLU7 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	160,421,711 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	43,338,808 bp
RNA expression pattern
	Top expressed in
	testicle; ; Achilles tendon; ; colon; ; superior frontal gyrus; ; sural nerve; ; prefrontal cortex; ; islet of Langerhans;
	Top expressed in
	saccule; ; otic vesicle; ; otic placode; ; genital tubercle; ; granulocyte; ; zygote; ; deep cerebellar nuclei; ; facial motor nucleus; ; vestibular sensory epithelium; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	pre-mRNA 3'-splice site binding; second spliceosomal transesterification activity; metal ion binding; protein binding; nucleic acid binding; zinc ion binding;
Cellular component	cytoplasm; nuclear speck; catalytic step 2 spliceosome; membrane; intracellular membrane-bounded organelle; small nuclear ribonucleoprotein complex; spliceosomal complex; nucleus; nucleoplasm; cytosol;
Biological process	cellular response to heat; RNA splicing, via transesterification reactions; mRNA processing; mRNA 3'-splice site recognition; RNA splicing; intracellular protein transport; alternative mRNA splicing, via spliceosome; RNA export from nucleus; mRNA splicing, via spliceosome; mRNA export from nucleus; mRNA 3'-end processing; termination of RNA polymerase II transcription;
	Sources:Amigo / QuickGO
Orthologs
	10569
	193116
	ENSG00000164609
	ENSMUSG00000020409
	O95391
	Q8BHJ9
	NM_006425
	NM_148673; NM_198936
NP_006416; NP_001351446; NP_001351447; NP_001351449; NP_001351450;
	NP_001351451; NP_001351452
	NP_683514; NP_945174
	Wikidata
View/Edit Human	View/Edit Mouse

Pre-mRNA-splicing factor SLU7 is a protein that in humans is encoded by the SLU7 gene.⁵⁶⁷

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions.⁷

References

GRCh38: Ensembl release 89: ENSG00000164609 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020409 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Chua K, Reed R (May 1999). "Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing". Genes Dev. 13 (7): 841–50. doi:10.1101/gad.13.7.841. PMC 316594. PMID 10197984.
Shomron N, Alberstein M, Reznik M, Ast G (Mar 2005). "Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing". J Cell Sci. 118 (Pt 6): 1151–9. doi:10.1242/jcs.01720. PMID 15728250. S2CID 18873022.
"Entrez Gene: SLU7 SLU7 splicing factor homolog (S. cerevisiae)".

Further reading

Alberstein M, Amit M, Vaknin K, et al. (2008). "Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing". RNA. 13 (11): 1988–99. doi:10.1261/rna.492907. PMC 2040095. PMID 17804646.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Shomron N, Reznik M, Ast G (2005). "Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus". Mol. Biol. Cell. 15 (8): 3782–95. doi:10.1091/mbc.E04-02-0152. PMC 491837. PMID 15181151.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chua K, Reed R (2001). "An upstream AG determines whether a downstream AG is selected during catalytic step II of splicing". Mol. Cell. Biol. 21 (5): 1509–14. doi:10.1128/MCB.21.5.1509-1514.2001. PMC 86697. PMID 11238888.
Chua K, Reed R (2000). "The RNA splicing factor hSlu7 is required for correct 3' splice-site choice". Nature. 402 (6758): 207–10. doi:10.1038/46086. PMID 10647016. S2CID 4428185.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164609 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020409 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10197984-5] Chua K, Reed R (May 1999). "Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing". Genes Dev. 13 (7): 841–50. doi:10.1101/gad.13.7.841. PMC 316594. PMID 10197984.

[pmid15728250-6] Shomron N, Alberstein M, Reznik M, Ast G (Mar 2005). "Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing". J Cell Sci. 118 (Pt 6): 1151–9. doi:10.1242/jcs.01720. PMID 15728250. S2CID 18873022.

[entrez-7] "Entrez Gene: SLU7 SLU7 splicing factor homolog (S. cerevisiae)".

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