SFRS3

SRSF3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2I38
Identifiers
Aliases	SRSF3, SFRS3, SRp20, serine/arginine-rich splicing factor 3, serine and arginine rich splicing factor 3
External IDs	OMIM: 603364; MGI: 98285; HomoloGene: 55708; GeneCards: SRSF3; OMA:SRSF3 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	36,605,600 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	29,262,347 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; monocyte; ; pericardium; ; thymus; ; mucosa of sigmoid colon; ; vena cava; ; lymph node; ; epithelium of nasopharynx; ; amniotic fluid;
	Top expressed in
	genital tubercle; ; ventricular zone; ; tail of embryo; ; medial ganglionic eminence; ; primitive streak; ; abdominal wall; ; embryo; ; embryo; ; neural tube; ; mandibular prominence;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; sequence-specific mRNA binding; protein binding; RNA binding;
Cellular component	nucleus; cytoplasm; nucleoplasm; nuclear speck;
Biological process	termination of RNA polymerase II transcription; mRNA 3'-end processing; mRNA splicing, via spliceosome; mRNA export from nucleus; mRNA transport; mRNA processing; RNA splicing; regulation of mRNA splicing, via spliceosome; RNA export from nucleus; transport; regulation of alternative mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	6428
	20383
	ENSG00000112081
	ENSMUSG00000071172
	P84103
	P84104
	NM_003017
	NM_013663
	NP_003008
	NP_038691
	Wikidata
View/Edit Human	View/Edit Mouse

Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene.⁵⁶

Browser View

UCSC Genome Browser View

UCSC Gene details page

Interactions

SFRS3 has been shown to interact with RBM7.⁷

References

GRCh38: Ensembl release 89: ENSG00000112081 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000071172 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Zahler AM; Lane WS; Stolk JA; Roth MB (Jun 1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes Dev. 6 (5): 837–47. doi:10.1101/gad.6.5.837. PMID 1577277.
"Entrez Gene: SFRS3 splicing factor, arginine/serine-rich 3".
Guo, Taylor B; Boros Laszlo G; Chan Kam C; Hikim Amiya P Sinha; Hudson Alan P; Swerdloff Ronald S; Mitchell Aaron P; Salameh Wael A (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors". J. Androl. 24 (2): 204–14. doi:10.1002/j.1939-4640.2003.tb02664.x. ISSN 0196-3635. PMID 12634307.

Further reading

Ayane M; Preuss U; Köhler G; Nielsen PJ (1991). "A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs". Nucleic Acids Res. 19 (6): 1273–8. doi:10.1093/nar/19.6.1273. PMC 333853. PMID 2030943.
Gui JF; Lane WS; Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID 8208298. S2CID 4275539. Archived from the original on 2020-12-03. Retrieved 2019-12-14.
Cáceres JF; Screaton GR; Krainer AR (1998). "A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm". Genes Dev. 12 (1): 55–66. doi:10.1101/gad.12.1.55. PMC 316398. PMID 9420331.
Zhang WJ; Wu JY (1998). "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing". Mol. Cell. Biol. 18 (2): 676–84. doi:10.1128/MCB.18.2.676. PMC 108778. PMID 9447963.
Tripodis N, Mason R, Humphray SJ, et al. (1999). "Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex". Genome Res. 8 (6): 631–43. doi:10.1101/gr.8.6.631. PMC 310739. PMID 9647638.
Papoutsopoulou S, Nikolakaki E, Chalepakis G, et al. (1999). "SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1". Nucleic Acids Res. 27 (14): 2972–80. doi:10.1093/nar/27.14.2972. PMC 148514. PMID 10390541.
Barnard DC; Patton JG (2000). "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein". Mol. Cell. Biol. 20 (9): 3049–57. doi:10.1128/MCB.20.9.3049-3057.2000. PMC 85584. PMID 10757789.
Shnyreva M, Schullery DS, Suzuki H, et al. (2000). "Interaction of two multifunctional proteins. Heterogeneous nuclear ribonucleoprotein K and Y-box-binding protein". J. Biol. Chem. 275 (20): 15498–503. doi:10.1074/jbc.275.20.15498. PMID 10809782.
Elliott DJ, Bourgeois CF, Klink A, et al. (2000). "A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 5717–22. Bibcode:2000PNAS...97.5717E. doi:10.1073/pnas.97.11.5717. PMC 18499. PMID 10823932.
Huang Y; Steitz JA (2001). "Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA". Mol. Cell. 7 (4): 899–905. doi:10.1016/S1097-2765(01)00233-7. PMID 11336712.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Barnard DC; Li J; Peng R; Patton JG (2002). "Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins". RNA. 8 (4): 526–33. doi:10.1017/S1355838202029928. PMC 1370273. PMID 11991645.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Guo TB, Boros LG, Chan KC, et al. (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors". J. Androl. 24 (2): 204–14. doi:10.1002/j.1939-4640.2003.tb02664.x. PMID 12634307.
Tai HH, Geisterfer M, Bell JC, et al. (2003). "CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins". Biochem. Biophys. Res. Commun. 308 (1): 170–6. doi:10.1016/S0006-291X(03)01354-8. PMID 12890497.
Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dettwiler S, Aringhieri C, Cardinale S, et al. (2005). "Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization" (PDF). J. Biol. Chem. 279 (34): 35788–97. doi:10.1074/jbc.M403927200. PMID 15169763. S2CID 39752996.
Lehner B; Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112081 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071172 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1577277-5] Zahler AM; Lane WS; Stolk JA; Roth MB (Jun 1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes Dev. 6 (5): 837–47. doi:10.1101/gad.6.5.837. PMID 1577277.

[entrez-6] "Entrez Gene: SFRS3 splicing factor, arginine/serine-rich 3".

[pmid12634307-7] Guo, Taylor B; Boros Laszlo G; Chan Kam C; Hikim Amiya P Sinha; Hudson Alan P; Swerdloff Ronald S; Mitchell Aaron P; Salameh Wael A (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors". J. Androl. 24 (2): 204–14. doi:10.1002/j.1939-4640.2003.tb02664.x. ISSN 0196-3635. PMID 12634307.

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