SESN3

SESN3
Identifiers
Aliases	SESN3, SEST3, sestrin 3
External IDs	OMIM: 607768; MGI: 1922997; HomoloGene: 14386; GeneCards: SESN3; OMA:SESN3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	95,232,541 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	14,244,397 bp
RNA expression pattern
	Top expressed in
	sperm; ; lateral nuclear group of thalamus; ; retinal pigment epithelium; ; internal globus pallidus; ; trigeminal ganglion; ; mucosa of paranasal sinus; ; epithelium of nasopharynx; ; Achilles tendon; ; spinal ganglia; ; external globus pallidus;
	Top expressed in
	ventromedial nucleus; ; lateral septal nucleus; ; molar; ; olfactory tubercle; ; saccule; ; mammillary body; ; ciliary body; ; nucleus accumbens; ; amygdala; ; retinal pigment epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; protein binding; oxidoreductase activity, acting on peroxide as acceptor; leucine binding;
Cellular component	nucleus; cytoplasm; GATOR2 complex; TORC2 complex;
Biological process	regulation of response to reactive oxygen species; negative regulation of TORC1 signaling; response to insulin; glucose homeostasis; regulation of protein kinase B signaling; TORC2 signaling; regulation of insulin receptor signaling pathway; cellular response to amino acid starvation; cellular response to glucose starvation; cellular response to amino acid stimulus; positive regulation of macroautophagy; cellular response to leucine; cellular response to leucine starvation;
	Sources:Amigo / QuickGO
Orthologs
	143686
	75747
	ENSG00000149212
	ENSMUSG00000032009
	P58005
	Q9CYP7
	NM_001271594; NM_144665
	NM_030261
	NP_001258523; NP_653266
	NP_084537
	Wikidata
View/Edit Human	View/Edit Mouse

Sestrin 3 is a protein that in humans is encoded by the SESN3 gene.⁵

Function

This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.

References

GRCh38: Ensembl release 89: ENSG00000149212 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000032009 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Sestrin 3". Retrieved 2017-08-05.

Further reading

Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Chen CC, Jeon SM, Bhaskar PT, Nogueira V, Sundararajan D, Tonic I, Park Y, Hay N (2010). "FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor". Dev. Cell. 18 (4): 592–604. doi:10.1016/j.devcel.2010.03.008. PMC 3031984. PMID 20412774.
Zamkova M, Khromova N, Kopnin BP, Kopnin P (2013). "Ras-induced ROS upregulation affecting cell proliferation is connected with cell type-specific alterations of HSF1/SESN3/p21Cip1/WAF1 pathways". Cell Cycle. 12 (5): 826–36. doi:10.4161/cc.23723. PMC 3610730. PMID 23388456.
Nascimento EB, Osler ME, Zierath JR (2013). "Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle". Am. J. Physiol. Endocrinol. Metab. 305 (11): E1408–14. doi:10.1152/ajpendo.00212.2013. PMC 3882372. PMID 24129397.
Vakana E, Arslan AD, Szilard A, Altman JK, Platanias LC (2013). "Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells". PLOS ONE. 8 (11) e78780. Bibcode:2013PLoSO...878780V. doi:10.1371/journal.pone.0078780. PMC 3832611. PMID 24260131.
Kang X, Petyaykina K, Tao R, Xiong X, Dong XC, Liangpunsakul S (2014). "The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury". Am. J. Physiol. Gastrointest. Liver Physiol. 307 (1): G58–65. doi:10.1152/ajpgi.00373.2013. PMC 4080163. PMID 24833709.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000149212 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032009 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Sestrin 3". Retrieved 2017-08-05.

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