SERPINB3

SERPINB3
Identifiers
Aliases	SERPINB3, HsT1196, SCC, SCCA-1, SCCA-PD, SCCA1, T4-A, SSCA1, serpin family B member 3
External IDs	OMIM: 600517; MGI: 2683295; HomoloGene: 130559; GeneCards: SERPINB3; OMA:SERPINB3 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ZV6, 4ZK0, 4ZK3
Gene location (Human)
Chr.	Chromosome 18 (human)
End	63,661,893 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	107,011,236 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; nasal epithelium; ; vulva; ; human penis; ; mucosa of paranasal sinus; ; epithelium of bronchus; ; bronchial epithelial cell; ; gums; ; gingival epithelium; ; mucosa of pharynx;
	Top expressed in
	thymus; ; esophagus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	virus receptor activity; protease binding; cysteine-type endopeptidase inhibitor activity; peptidase inhibitor activity; serine-type endopeptidase inhibitor activity;
Cellular component	nucleus; vesicle; cytoplasmic vesicle; extracellular exosome; cytoplasm; extracellular region; extracellular space; azurophil granule lumen;
Biological process	paracrine signaling; positive regulation of cell population proliferation; autocrine signaling; negative regulation of catalytic activity; negative regulation of JUN kinase activity; positive regulation of endopeptidase activity; positive regulation of epithelial to mesenchymal transition; negative regulation of proteolysis; negative regulation of endopeptidase activity; positive regulation of cell migration; viral entry into host cell; negative regulation of peptidase activity; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	6317
	394252
	ENSG00000057149
	ENSMUSG00000058017
	P29508
	Q6UKZ0
	NM_006919
	NM_201376
	NP_008850
	NP_958764
	Wikidata
View/Edit Human	View/Edit Mouse

Serpin B3 is a protein that in humans is encoded by the SERPINB3 gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000057149 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000058017 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, et al. (May 1995). "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene". Proceedings of the National Academy of Sciences of the United States of America. 92 (8): 3147–3151. Bibcode:1995PNAS...92.3147S. doi:10.1073/pnas.92.8.3147. PMC 42122. PMID 7724531.
"Entrez Gene: SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3".

Further reading

Suminami Y, Kishi F, Sekiguchi K, Kato H (1992). "Squamous cell carcinoma antigen is a new member of the serine protease inhibitors". Biochemical and Biophysical Research Communications. 181 (1): 51–58. doi:10.1016/S0006-291X(05)81380-4. PMID 1958219.
Mino-Miyagawa N, Kimura Y, Hamamoto K (1990). "Tumor-antigen 4. Its immunohistochemical distribution and tissue and serum concentrations in squamous cell carcinoma of the lung and esophagus". Cancer. 66 (7): 1505–1512. doi:10.1002/1097-0142(19901001)66:7<1505::AID-CNCR2820660712>3.0.CO;2-V. PMID 2208001. S2CID 8673447.
Mino N, Iio A, Hamamoto K (1988). "Availability of tumor-antigen 4 as a marker of squamous cell carcinoma of the lung and other organs". Cancer. 62 (4): 730–734. doi:10.1002/1097-0142(19880815)62:4<730::AID-CNCR2820620415>3.0.CO;2-W. PMID 2840187. S2CID 33396329.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Schick C, Pemberton PA, Shi GP, Kamachi Y, Cataltepe S, Bartuski AJ, et al. (April 1998). "Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis". Biochemistry. 37 (15): 5258–5266. doi:10.1021/bi972521d. PMID 9548757.
Cataltepe S, Gornstein ER, Schick C, Kamachi Y, Chatson K, Fries J, et al. (January 2000). "Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas". The Journal of Histochemistry and Cytochemistry. 48 (1): 113–122. doi:10.1177/002215540004800112. PMID 10653592.
Uemura Y, Pak SC, Luke C, Cataltepe S, Tsu C, Schick C, et al. (July 2000). "Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells". International Journal of Cancer. 89 (4): 368–377. doi:10.1002/1097-0215(20000720)89:4<368::AID-IJC9>3.0.CO;2-6. PMID 10956412. S2CID 23697095.
Hamada K, Shinomiya H, Asano Y, Kihana T, Iwamoto M, Hanakawa Y, et al. (March 2001). "Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter". Biochimica et Biophysica Acta. 1518 (1–2): 124–131. doi:10.1016/s0167-4781(01)00174-9. PMID 11267667.
Shimada H, Nabeya Y, Okazumi S, Matsubara H, Shiratori T, Gunji Y, et al. (May 2003). "Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma". Surgery. 133 (5): 486–494. doi:10.1067/msy.2003.139. PMID 12773976.
Micke O, Bruns F, Schäfer U, Horst E, Büntzel J, Willich N (2003). "The clinical value of squamous cell carcinoma antigen in patients irradiated for locally advanced cancer of the head and neck". Anticancer Research. 23 (2A): 907–911. PMID 12820321.
Nawata S, Nakamura K, Hirakawa H, Sueoka K, Emoto T, Murakami A, et al. (July 2003). "Electrophoretic analysis of the cleaved form of serpin, squamous cell carcinoma antigen-1 in normal and malignant squamous epithelial tissues". Electrophoresis. 24 (14): 2277–2282. doi:10.1002/elps.200305501. PMID 12874860. S2CID 41852542.
Masumoto K, Sakata Y, Arima K, Nakao I, Izuhara K (November 2003). "Inhibitory mechanism of a cross-class serpin, the squamous cell carcinoma antigen 1". The Journal of Biological Chemistry. 278 (46): 45296–45304. doi:10.1074/jbc.M307741200. PMID 12949073.
Moore PL, Ong S, Harrison TJ (2004). "Squamous cell carcinoma antigen 1-mediated binding of hepatitis B virus to hepatocytes does not involve the hepatic serpin clearance system". The Journal of Biological Chemistry. 278 (47): 46709–46717. doi:10.1074/jbc.M302842200. PMID 12975381.
Onishi A, Nakashiro K, Mihara M, Sumida T, Kawamata H, Shintani S, et al. (January 2004). "Basic and clinical studies on quantitative analysis of lymph node micrometastasis in oral cancer". Oncology Reports. 11 (1): 33–39. doi:10.3892/or.11.1.33. PMID 14654899.
Hirakawa H, Nawata S, Sueoka K, Murakami A, Takeda O, Numa F, et al. (February 2004). "Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line". Oncology Reports. 11 (2): 415–419. doi:10.3892/or.11.2.415. PMID 14719077.
Pontisso P, Calabrese F, Benvegnù L, Lise M, Belluco C, Ruvoletto MG, et al. (February 2004). "Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma". British Journal of Cancer. 90 (4): 833–837. doi:10.1038/sj.bjc.6601543. PMC 2410161. PMID 14970861.
Ruvoletto MG, Tono N, Carollo D, Vilei T, Trentin L, Muraca M, et al. (March 2004). "Surface expression of squamous cell carcinoma antigen (SCCA) can be increased by the preS1(21-47) sequence of hepatitis B virus". The Journal of General Virology. 85 (Pt 3): 621–624. doi:10.1099/vir.0.19130-0. hdl:11577/2436607. PMID 14993646.
Turato C, Ruvoletto MG, Biasiolo A, Quarta S, Tono N, Bernardinello E, et al. (March 2009). "Squamous cell carcinoma antigen-1 (SERPINB3) polymorphism in chronic liver disease". Digestive and Liver Disease. 41 (3): 212–216. doi:10.1016/j.dld.2008.06.001. PMID 18657489.

External links

The MEROPS online database for peptidases and their inhibitors: I04.008
SERPINB3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000057149 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058017 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7724531-5] Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, et al. (May 1995). "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene". Proceedings of the National Academy of Sciences of the United States of America. 92 (8): 3147–3151. Bibcode:1995PNAS...92.3147S. doi:10.1073/pnas.92.8.3147. PMC 42122. PMID 7724531.

[entrez-6] "Entrez Gene: SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3".

1

2

3

4

5

6

See also

References

Further reading

External links