SEPT3

SEPTIN3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3SOP, 4Z51, 4Z54
Identifiers
Aliases	SEPTIN3, SEP3, bK250D10.3, septin 3, SEPT3
External IDs	OMIM: 608314; MGI: 1345148; HomoloGene: 99740; GeneCards: SEPTIN3; OMA:SEPTIN3 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	41,998,221 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	82,178,775 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; right frontal lobe; ; ventricular zone; ; dorsolateral prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; prefrontal cortex; ; Brodmann area 9; ; cerebellar hemisphere; ; amygdala;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; cerebellar vermis; ; superior frontal gyrus; ; lobe of cerebellum; ; primary visual cortex; ; subiculum; ; piriform cortex; ; cingulate gyrus; ; primary motor cortex; ; hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; identical protein binding; molecular function; GTPase activity; molecular adaptor activity;
Cellular component	cytoplasm; cell junction; synapse; cytoskeleton; septin ring; microtubule cytoskeleton; septin complex; septin filament array; neuron projection; presynaptic cytoskeleton; presynapse;
Biological process	cell cycle; cell division; mitotic cytokinesis; septin ring assembly; cilium assembly; cytoskeleton-dependent cytokinesis;
	Sources:Amigo / QuickGO
Orthologs
	55964
	24050
	ENSG00000100167
	ENSMUSG00000022456
	Q9UH03
	Q9Z1S5
	NM_145734; NM_019106; NM_145733; NM_001363845
NM_011889; NM_001358836; NM_001358837; NM_001368642; NM_001368643;
	NM_001368644; NM_001368645; NM_001368646; NM_001368647; NM_001368784; NM_001368785
	NP_061979; NP_663786; NP_001350774
	NP_036019; NP_001345765; NP_001345766
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal-specific septin-3 is a protein that in humans is encoded by the SEPT3 gene.⁵

Function

This gene belongs to the septin family of GTPases. Members of this family are required for cytokinesis. Expression is upregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of this gene has not been determined. Alternative splicing of this gene results in multiple transcript variants.⁵

References

GRCh38: Ensembl release 89: ENSG00000100167 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022456 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: SEPT3 septin 3".

Further reading

Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Methner A, Leypoldt F, Joost P, Lewerenz J (April 2001). "Human septin 3 on chromosome 22q13.2 is upregulated by neuronal differentiation". Biochemical and Biophysical Research Communications. 283 (1): 48–56. doi:10.1006/bbrc.2001.4741. PMID 11322766.
Xue J, Milburn PJ, Hanna BT, Graham ME, Rostas JA, Robinson PJ (August 2004). "Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein kinase-I in nerve terminals". The Biochemical Journal. 381 (Pt 3): 753–60. doi:10.1042/BJ20040455. PMC 1133885. PMID 15107017.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Xue J, Tsang CW, Gai WP, Malladi CS, Trimble WS, Rostas JA, Robinson PJ (November 2004). "Septin 3 (G-septin) is a developmentally regulated phosphoprotein enriched in presynaptic nerve terminals". Journal of Neurochemistry. 91 (3): 579–90. doi:10.1111/j.1471-4159.2004.02755.x. PMID 15485489. S2CID 2730644.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100167 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022456 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SEPT3 septin 3".

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