SEPT12

SEPTIN12
Identifiers
Aliases	SEPTIN12, SPGF10, septin 12, SEPT12
External IDs	OMIM: 611562; MGI: 1918339; HomoloGene: 69435; GeneCards: SEPTIN12; OMA:SEPTIN12 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	4,788,398 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	4,815,716 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; testicle; ; cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; primary visual cortex; ; C1 segment; ; medulla oblongata; ; mucosa of transverse colon;
	Top expressed in
	seminiferous tubule; ; spermatocyte; ; spermatid; ; blastocyst; ; morula; ; secondary oocyte; ; gastrula; ; zygote; ; primary oocyte; ; mucosa of small intestine;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; phosphatidylinositol binding; protein homodimerization activity; GDP binding; identical protein binding; GTPase activity; molecular adaptor activity;
Cellular component	cytoplasm; microtubule cytoskeleton; perinuclear region of cytoplasm; sperm annulus; spindle; cell projection; midbody; cleavage furrow; motile cilium; cytoskeleton; cilium; stress fiber; septin complex; nucleus; septin ring; septin filament array;
Biological process	cell cycle; cell division; sperm motility; spermatogenesis; cell differentiation; flagellated sperm motility; mitotic cytokinesis; septin ring assembly; cilium assembly; cytoskeleton-dependent cytokinesis;
	Sources:Amigo / QuickGO
Orthologs
	124404
	71089
	ENSG00000140623
	ENSMUSG00000022542
	Q8IYM1
	n/a
	NM_001154458; NM_144605
	NM_027669; NM_029374; NM_001373945
	NP_001147930; NP_653206
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Septin 12 is a protein that in humans is encoded by the SEPT12 gene.⁵

Function

This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene.⁵

References

GRCh38: Ensembl release 89: ENSG00000140623 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022542 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Septin 12".

External links

Overview of all the structural information available in the PDB for UniProt: Q8IYM1 (Septin-12) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140623 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022542 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Septin 12".

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Function

References

Further reading

External links