SEMA6A

SEMA6A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3AFC, 3AL8, 3OKW, 3OKY
Identifiers
Aliases	SEMA6A, HT018, SEMA, SEMA6A1, SEMAQ, VIA, semaphorin 6A
External IDs	OMIM: 605885; MGI: 1203727; HomoloGene: 32426; GeneCards: SEMA6A; OMA:SEMA6A - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	116,574,823 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	47,501,937 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; external globus pallidus; ; subthalamic nucleus; ; corpus callosum; ; jejunal mucosa; ; lateral nuclear group of thalamus; ; pars reticulata; ; ventral tegmental area; ; superior vestibular nucleus; ; pons;
	Top expressed in
	tail of embryo; ; genital tubercle; ; lumbar subsegment of spinal cord; ; yolk sac; ; Dermatocranium; ; membranous bone; ; epiblast; ; mandible; ; cartilage of the septum; ; medial geniculate nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; semaphorin receptor binding; chemorepellent activity;
Cellular component	integral component of membrane; axon; plasma membrane; membrane; integral component of plasma membrane; extracellular space;
Biological process	animal organ morphogenesis; multicellular organism development; cell surface receptor signaling pathway; cell differentiation; cytoskeleton organization; nervous system development; apoptotic process; axon guidance; positive regulation of neuron migration; negative regulation of sprouting angiogenesis; negative regulation of angiogenesis; negative regulation of cell adhesion involved in sprouting angiogenesis; cellular response to vascular endothelial growth factor stimulus; negative regulation of ERK1 and ERK2 cascade; negative regulation of vascular endothelial growth factor signaling pathway; neural crest cell migration; positive regulation of cell migration; negative regulation of axon extension involved in axon guidance; negative chemotaxis; semaphorin-plexin signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	57556
	20358
	ENSG00000092421
	ENSMUSG00000019647
	Q9H2E6
	O35464
	NM_001300780; NM_020681; NM_020796
	NM_018744; NM_001311097
	NP_001287709; NP_065847
	NP_001298026; NP_061214
	Wikidata
View/Edit Human	View/Edit Mouse

Semaphorin-6A is a protein that in humans is encoded by the SEMA6A gene.⁵⁶⁷

In melanocytic cells SEMA6A gene expression may be regulated by MITF.⁸

References

GRCh38: Ensembl release 89: ENSG00000092421 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000019647 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Zhou L, White FA, Lentz SI, Wright DE, Fisher DA, Snider WD (Sep 1997). "Cloning and expression of a novel murine semaphorin with structural similarity to insect semaphorin I". Mol Cell Neurosci. 9 (1): 26–41. doi:10.1006/mcne.1997.0607. PMID 9204478. S2CID 38730386.
Klostermann A, Lutz B, Gertler F, Behl C (Jan 2001). "The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain". J Biol Chem. 275 (50): 39647–53. doi:10.1074/jbc.M006316200. PMID 10993894.
"Entrez Gene: SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A".
Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

Further reading

Prislei S, Mozzetti S, Filippetti F, et al. (2008). "From plasma membrane to cytoskeleton: a novel function for semaphorin 6A". Mol. Cancer Ther. 7 (1): 233–41. doi:10.1158/1535-7163.MCT-07-0390. PMID 18187809.
Katoh M, Katoh M (2007). "Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells". Int. J. Mol. Med. 20 (3): 405–9. doi:10.3892/ijmm.20.3.405. PMID 17671748.
Gautier G, de Saint-Vis B, Sénéchal B, et al. (2006). "The class 6 semaphorin SEMA6A is induced by interferon-gamma and defines an activation status of langerhans cells observed in pathological situations". Am. J. Pathol. 168 (2): 453–65. doi:10.2353/ajpath.2006.050288. PMC 1606484. PMID 16436660.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000092421 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019647 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9204478-5] Zhou L, White FA, Lentz SI, Wright DE, Fisher DA, Snider WD (Sep 1997). "Cloning and expression of a novel murine semaphorin with structural similarity to insect semaphorin I". Mol Cell Neurosci. 9 (1): 26–41. doi:10.1006/mcne.1997.0607. PMID 9204478. S2CID 38730386.

[pmid10993894-6] Klostermann A, Lutz B, Gertler F, Behl C (Jan 2001). "The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain". J Biol Chem. 275 (50): 39647–53. doi:10.1074/jbc.M006316200. PMID 10993894.

[entrez-7] "Entrez Gene: SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A".

[pmid19067971-8] Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

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