SEMA4G

SEMA4G
Identifiers
Aliases	SEMA4G, semaphorin 4G
External IDs	MGI: 1347047; HomoloGene: 22682; GeneCards: SEMA4G; OMA:SEMA4G - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	100,985,871 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	45,003,397 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; right lobe of liver; ; mucosa of ileum; ; right hemisphere of cerebellum; ; body of pancreas; ; right ovary; ; left ovary; ; right lobe of thyroid gland; ; skin of leg;
	Top expressed in
	left lobe of liver; ; crypt of lieberkuhn of small intestine; ; epithelium of small intestine; ; colon; ; left colon; ; duodenum; ; right lobe of liver; ; jejunum; ; cerebellar cortex; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; neuropilin binding; semaphorin receptor binding; chemorepellent activity;
Cellular component	integral component of membrane; plasma membrane; membrane; extracellular space; integral component of plasma membrane;
Biological process	multicellular organism development; cell differentiation; nervous system development; negative chemotaxis; neural crest cell migration; positive regulation of cell migration; negative regulation of axon extension involved in axon guidance; semaphorin-plexin signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	57715
	26456
	ENSG00000095539
	ENSMUSG00000025207
	Q9NTN9
	Q9WUH7
	NM_001203244; NM_017893
	NM_011976
	NP_001190173; NP_060363
	NP_036106
	Wikidata
View/Edit Human	View/Edit Mouse

Semaphorin-4G is a protein in humans encoded by the SEMA4G gene.⁵

Semaphorins are a large family of conserved, secreted and membrane associated proteins which possess a semaphoring (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Semaphorins maintain cell motility and attachment in axon guidance, immune cell maintenance, vascular growth and tumour movement.⁶

Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene and the gene for mitochondrial ribosomal protein L43 overlap at map location 10q24.31 and are transcribed in opposite directions.⁵

References

GRCh38: Ensembl release 89: ENSG00000095539 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025207 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G".
Kruger, Robert P.; Aurandt, Jennifer; Guan, Kun-Liang (October 2005). "Semaphorins command cells to move". Nature Reviews Molecular Cell Biology. 6 (10): 789–800. doi:10.1038/nrm1740. ISSN 1471-0080.

Further reading

Pasterkamp RJ, Kolodkin AL (2003). "Semaphorin junction: making tracks toward neural connectivity". Curr. Opin. Neurobiol. 13 (1): 79–89. doi:10.1016/S0959-4388(03)00003-5. PMID 12593985. S2CID 40661992.
Dickson BJ (2003). "Molecular mechanisms of axon guidance". Science. 298 (5600): 1959–64. doi:10.1126/science.1072165. PMID 12471249. S2CID 28328792.
Holtmaat AJ, De Winter F, De Wit J, et al. (2002). "Semaphorins: Contributors to structural stability of hippocampal networks?". Plasticity in the Adult Brain: From Genes to Neurotherapy. Progress in Brain Research. Vol. 138. pp. 17–38. doi:10.1016/S0079-6123(02)38068-3. ISBN 978-0-444-50981-9. PMID 12432760. {{cite book}}: |journal= ignored (help)
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000095539 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025207 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G".

[6] Kruger, Robert P.; Aurandt, Jennifer; Guan, Kun-Liang (October 2005). "Semaphorins command cells to move". Nature Reviews Molecular Cell Biology. 6 (10): 789–800. doi:10.1038/nrm1740. ISSN 1471-0080.

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