Article · Wikipedia archive · Last revised Jun 12, 2026

Secofentanyl

Secofentanyl is an opioid derivative which is an analogue of fentanyl where the piperidine ring has been cleaved to form an open-chain structure. It is around 40× less potent than fentanyl itself but still 5–6× the potency of morphine in animal tests.

Last revised
Jun 12, 2026
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≈ 1 min
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Secofentanyl
Identifiers
  • N-[4-[methyl(2-phenylethyl)amino]butan-2-yl]-N-phenylpropanamide
CAS Number
PubChem CID
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC22H30N2O
Molar mass338.495 g·mol−1
3D model (JSmol)
  • CCC(=O)N(C1=CC=CC=C1)C(C)CCN(C)CCC2=CC=CC=C2
  • InChI=1S/C22H30N2O/c1-4-22(25)24(21-13-9-6-10-14-21)19(2)15-17-23(3)18-16-20-11-7-5-8-12-20/h5-14,19H,4,15-18H2,1-3H3
  • Key:TVSLDWMMAUJGPV-UHFFFAOYSA-N

Secofentanyl is an opioid derivative which is an analogue of fentanyl where the piperidine ring has been cleaved to form an open-chain structure. It is around 40× less potent than fentanyl itself but still 5–6× the potency of morphine in animal tests.12

See also

See also

References

References

  1. Ivanović MD, Mićović I, Vučković S, Prostran M, Todorović Z, Ivanović E, Kiricojević V, Đorđević JB, Došen-Mićović L (2004). "The synthesis and pharmacological evaluation of (+/-)-2, 3-seco-fentanyl analogues". Journal of the Serbian Chemical Society. 69 (11): 955–68. doi:10.2298/JSC0411955I.
  2. Lipiński PF, Kosson P, Matalińska J, Roszkowski P, Czarnocki Z, Jarończyk M, Misicka A, Dobrowolski JC, Sadlej J (February 2019). "Fentanyl Family at the Mu-Opioid Receptor: Uniform Assessment of Binding and Computational Analysis". Molecules (Basel, Switzerland). 24 (4): 740. doi:10.3390/molecules24040740. PMC 6412969. PMID 30791394.